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rdf:type |
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lifeskim:mentions |
umls-concept:C0007452,
umls-concept:C0017262,
umls-concept:C0021311,
umls-concept:C0021745,
umls-concept:C0030524,
umls-concept:C0034131,
umls-concept:C0085295,
umls-concept:C0085442,
umls-concept:C0185117,
umls-concept:C0229664,
umls-concept:C1446680,
umls-concept:C1948023,
umls-concept:C1955304,
umls-concept:C2349975,
umls-concept:C2911684
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pubmed:issue |
4
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pubmed:dateCreated |
2004-3-24
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pubmed:abstractText |
Monoclonal antibody neutralization of interleukin-10 (IL-10) increased Johnin purified protein derivative-induced whole-blood gamma interferon (IFN-gamma) secretion 23-fold and also increased IFN-gamma secretion ninefold following in vitro Mycobacterium avium subsp. paratuberculosis infection of peripheral blood mononuclear cells. These results demonstrate the suppressive effect of IL-10 on immune responses to M. avium subsp. paratuberculosis infection in cattle.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039374-10895895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039374-11432810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039374-11943322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039374-12065529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039374-12228282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039374-14638822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039374-1632724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039374-1827484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039374-6375961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039374-8844578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039374-9125559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039374-9147244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039374-9256958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039374-9659548
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2425-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15039374-Animals,
pubmed-meshheading:15039374-Cattle,
pubmed-meshheading:15039374-Cattle Diseases,
pubmed-meshheading:15039374-Interferon-gamma,
pubmed-meshheading:15039374-Interleukin-10,
pubmed-meshheading:15039374-Leukocytes, Mononuclear,
pubmed-meshheading:15039374-Mycobacterium avium subsp. paratuberculosis,
pubmed-meshheading:15039374-Neutralization Tests,
pubmed-meshheading:15039374-Paratuberculosis,
pubmed-meshheading:15039374-Tuberculin,
pubmed-meshheading:15039374-Up-Regulation
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pubmed:year |
2004
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pubmed:articleTitle |
Neutralization of interleukin-10 significantly enhances gamma interferon expression in peripheral blood by stimulation with Johnin purified protein derivative and by infection with Mycobacterium avium subsp. paratuberculosis in experimentally infected cattle with paratuberculosis.
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pubmed:affiliation |
Paratuberculosis and Inflammatory Bowel Disease Research Team. Immune System Section, National Institute of Animal Health. Molecular Immunology Laboratory, National Institute of Agrobiological Sciences, 3-1-5 Kan-nondai, Tsukuba 305-0856, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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