|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0026809,
umls-concept:C0026926,
umls-concept:C0079189,
umls-concept:C0132555,
umls-concept:C0185117,
umls-concept:C0221099,
umls-concept:C0332281,
umls-concept:C0683598,
umls-concept:C0870432,
umls-concept:C1423842,
umls-concept:C1517945,
umls-concept:C1555465,
umls-concept:C1705417,
umls-concept:C2911684
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2004-3-24
|
|
pubmed:abstractText |
Mycobacterium tuberculosis possesses agonists for several Toll-like receptors (TLRs), yet mice with single TLR deletions are resistant to acute tuberculosis. MyD88(-/-) mice were used to examine whether TLRs play any role in protection against aerogenic M. tuberculosis H37Rv infection. MyD88(-/-) mice failed to control mycobacterial replication and rapidly succumbed. Moreover, expressions of interleukin 12, tumor necrosis factor alpha, gamma interferon, and nitric oxide synthase 2 were markedly decreased in the knockout animals. These results argue that resistance to M. tuberculosis must depend on MyD88-dependent signals mediated by an as-yet-undetermined TLR or a combination of TLRs.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-10225924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-10426995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-10490993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-10588727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-10830786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-10934223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-10950787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-11067888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-11238656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-11244032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-11254633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-11404392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-11698470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-11861613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-12055206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-12077261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-12218133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-12244136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-12244183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-12244184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-12825894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-12900270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-14517275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-14568952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-14638995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-7504064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-8245795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15039368-9697844
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Myd88 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloid Differentiation Factor 88,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0019-9567
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
72
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2400-4
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:15039368-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:15039368-Animals,
pubmed-meshheading:15039368-Antigens, Differentiation,
pubmed-meshheading:15039368-Cytokines,
pubmed-meshheading:15039368-Lung,
pubmed-meshheading:15039368-Mice,
pubmed-meshheading:15039368-Mice, Inbred C57BL,
pubmed-meshheading:15039368-Mice, Knockout,
pubmed-meshheading:15039368-Mycobacterium tuberculosis,
pubmed-meshheading:15039368-Myeloid Differentiation Factor 88,
pubmed-meshheading:15039368-Nitric Oxide Synthase,
pubmed-meshheading:15039368-Receptors, Immunologic,
pubmed-meshheading:15039368-Th1 Cells,
pubmed-meshheading:15039368-Tuberculosis, Pulmonary,
pubmed-meshheading:15039368-Virulence
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
MyD88-deficient mice display a profound loss in resistance to Mycobacterium tuberculosis associated with partially impaired Th1 cytokine and nitric oxide synthase 2 expression.
|
|
pubmed:affiliation |
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. cscanga@miaid.nih.gov
|
|
pubmed:publicationType |
Journal Article
|
