rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-3-24
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pubmed:abstractText |
Acrylamide inhibits creatine kinase (CK) activities in the brain of rats or mice. However, its effects on genetic expression of CK have not yet been studied. CK mRNA and protein level were examined by RT-PCR and Western blotting, respectively. Neither cytosolic CK (B subunit) and mitochondrial CK (ubiquitous form) mRNA nor B subunit protein was clearly changed in the cerebellum from rats intoxicated with acrylamide (50 mg/kg/day i.p. for 8 days) and showing clinical neurotoxic signs.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
|
pubmed:issn |
0387-821X
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
1
|
pubmed:volume |
26
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
51-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15038071-Acrylamide,
pubmed-meshheading:15038071-Animals,
pubmed-meshheading:15038071-Blotting, Western,
pubmed-meshheading:15038071-Carboxypeptidases,
pubmed-meshheading:15038071-Cerebellum,
pubmed-meshheading:15038071-Creatine Kinase,
pubmed-meshheading:15038071-Cytosol,
pubmed-meshheading:15038071-Gene Expression,
pubmed-meshheading:15038071-Male,
pubmed-meshheading:15038071-Mitochondria,
pubmed-meshheading:15038071-Proteins,
pubmed-meshheading:15038071-RNA, Messenger,
pubmed-meshheading:15038071-Rats,
pubmed-meshheading:15038071-Rats, Wistar,
pubmed-meshheading:15038071-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2004
|
pubmed:articleTitle |
Acrylamide does not cause apparent changes in genetic expression of creatine kinase in rat cerebellum.
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pubmed:affiliation |
Department of Environmental Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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