Linked Life Data

15037868

Source:http://linkedlifedata.com/resource/pubmed/id/15037868

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2004-6-25
pubmed:abstractText
The broad variation in phenotypes and severities within autism spectrum disorders suggests the involvement of multiple predisposing factors, interacting in complex ways with normal developmental courses and gradients. Identification of these factors, and the common developmental path into which they feed, is hampered by the large degrees of convergence from causal factors to altered brain development, and divergence from abnormal brain development into altered cognition and behaviour. Genetic, neurochemical, neuroimaging, and behavioural findings on autism, as well as studies of normal development and of genetic syndromes that share symptoms with autism, offer hypotheses as to the nature of causal factors and their possible effects on the structure and dynamics of neural systems. Such alterations in neural properties may in turn perturb activity-dependent development, giving rise to a complex behavioural syndrome many steps removed from the root causes. Animal models based on genetic, neurochemical, neurophysiological, and behavioural manipulations offer the possibility of exploring these developmental processes in detail, as do human studies addressing endophenotypes beyond the diagnosis itself.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1359-4184
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
646-63
pubmed:dateRevised
2005-6-8
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Autism as a disorder of neural information processing: directions for research and targets for therapy.
pubmed:affiliation
Autism Research Centre, Departments of Psychiatry and Experimental Psychology, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge CB2 2AH, UK. belmonte@mit.edu
pubmed:publicationType
Journal Article, Review