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rdf:type |
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lifeskim:mentions |
umls-concept:C0023789,
umls-concept:C0035331,
umls-concept:C0035820,
umls-concept:C0392747,
umls-concept:C0443172,
umls-concept:C0449432,
umls-concept:C0993609,
umls-concept:C1179435,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1705248
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|
pubmed:issue |
4
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|
pubmed:dateCreated |
2004-3-23
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|
pubmed:abstractText |
Lipofuscin accumulates in human retinal pigment epithelium (RPE) cells with age and may be the main factor responsible for the increasing susceptibility of RPE to photo-oxidation with age. As the composition, absorption, and fluorescence of lipofuscin undergo age-related changes, the purpose of this study was to determine whether photoreactivity of lipofuscin granules also changes with the donor age.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
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pubmed:issn |
0146-0404
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1052-60
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pubmed:dateRevised |
2010-3-24
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pubmed:meshHeading |
pubmed-meshheading:15037568-Adolescent,
pubmed-meshheading:15037568-Adult,
pubmed-meshheading:15037568-Aged,
pubmed-meshheading:15037568-Aged, 80 and over,
pubmed-meshheading:15037568-Aging,
pubmed-meshheading:15037568-Child,
pubmed-meshheading:15037568-Child, Preschool,
pubmed-meshheading:15037568-Chloroform,
pubmed-meshheading:15037568-Electron Spin Resonance Spectroscopy,
pubmed-meshheading:15037568-Humans,
pubmed-meshheading:15037568-Infant,
pubmed-meshheading:15037568-Lipofuscin,
pubmed-meshheading:15037568-Middle Aged,
pubmed-meshheading:15037568-Oxidative Stress,
pubmed-meshheading:15037568-Oxygen,
pubmed-meshheading:15037568-Pigment Epithelium of Eye,
pubmed-meshheading:15037568-Reactive Oxygen Species,
pubmed-meshheading:15037568-Solubility,
pubmed-meshheading:15037568-Spin Trapping,
pubmed-meshheading:15037568-Superoxides,
pubmed-meshheading:15037568-Tissue Donors,
pubmed-meshheading:15037568-Vision, Ocular
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pubmed:year |
2004
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pubmed:articleTitle |
Age-related changes in the photoreactivity of retinal lipofuscin granules: role of chloroform-insoluble components.
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pubmed:affiliation |
Department of Biophysics, Faculty of Biotechnology, Kraków, Poland. School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom. rozanowskamb@cf.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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