Linked Life Data

15034585

Source:http://linkedlifedata.com/resource/pubmed/id/15034585

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-3-29
pubmed:abstractText
Morphological plasticity of dendritic spines and synapses is thought to be crucial for their physiological functions. Here we show that alpha N-catenin, a linker between cadherin adhesion receptors and the actin cytoskeleton, is essential for stabilizing dendritic spines in rodent hippocampal neurons in culture. In the absence of alpha N-catenin, spine heads were abnormally motile, actively protruding filopodia from their synaptic contact sites. Conversely, alpha N-catenin overexpression in dendrites reduced spine turnover, causing an increase in spine and synapse density. Tetrodotoxin (TTX), a neural activity blocker, suppressed the synaptic accumulation of alpha N-catenin, whereas bicuculline, a GABA antagonist, promoted it. Furthermore, excess alpha N-catenin rendered spines resistant to the TTX treatment. These results suggest that alpha N-catenin is a key regulator for the stability of synaptic contacts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1097-6256
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
357-63
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Stability of dendritic spines and synaptic contacts is controlled by alpha N-catenin.
pubmed:affiliation
RIKEN Center for Developmental Biology, 2-2-3 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't