Source:http://linkedlifedata.com/resource/pubmed/id/15034568
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2004-4-1
|
| pubmed:databankReference | |
| pubmed:abstractText |
Genomic amplification at 20q11-13 is a common event in human cancers. We isolated a germline translocation breakpoint at 20q11 from a bladder cancer patient. We identified CDC91L1, the gene encoding CDC91L1 (also called phosphatidylinositol glycan class U (PIG-U), a transamidase complex unit in the glycosylphosphatidylinositol (GPI) anchoring pathway), as the only gene whose expression was affected by the translocation. CDC91L1 was amplified and overexpressed in about one-third of bladder cancer cell lines and primary tumors, as well as in oncogenic uroepithelial cells transformed with human papillomavirus (HPV) E7. Forced overexpression of CDC91L1 malignantly transformed NIH3T3 cells in vitro and in vivo. Overexpression of CDC91L1 also resulted in upregulation of the urokinase receptor (uPAR), a GPI-anchored protein, and in turn increased STAT-3 phosphorylation in bladder cancer cells. Our findings suggest that CDC91L1 is an oncogene in bladder cancer, and implicate the GPI anchoring system as a potential oncogenic pathway and therapeutic target in human cancers.
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| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1078-8956
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| pubmed:author |
pubmed-author:AnzickSarah LSL,
pubmed-author:CohenYoramY,
pubmed-author:EisenbergerClaus FCF,
pubmed-author:EnglesJames MJM,
pubmed-author:FomenkovAlexeyA,
pubmed-author:GuoZhongminZ,
pubmed-author:HalachmiSarelS,
pubmed-author:HoqueMohammad ObaidulMO,
pubmed-author:KiemeneyLambertus ALA,
pubmed-author:LinnJürgen FJF,
pubmed-author:MeltzerPaul SPS,
pubmed-author:MoonChulsoC,
pubmed-author:OkamiKenjiK,
pubmed-author:OsadaMotonabuM,
pubmed-author:RatovitskiEdwardE,
pubmed-author:SchoenbergMark PMP,
pubmed-author:SidranskyDavidD,
pubmed-author:SteinerGabrielG,
pubmed-author:TrentJeffrey MJM,
pubmed-author:TrinkBarryB,
pubmed-author:WestraWilliam HWH,
pubmed-author:WuGuojunG
|
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
374-81
|
| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:15034568-Animals,
pubmed-meshheading:15034568-Chromosomes, Human, Pair 20,
pubmed-meshheading:15034568-Cloning, Molecular,
pubmed-meshheading:15034568-Fluorescent Antibody Technique,
pubmed-meshheading:15034568-Humans,
pubmed-meshheading:15034568-In Situ Hybridization, Fluorescence,
pubmed-meshheading:15034568-Mice,
pubmed-meshheading:15034568-Molecular Sequence Data,
pubmed-meshheading:15034568-NIH 3T3 Cells,
pubmed-meshheading:15034568-Oncogenes,
pubmed-meshheading:15034568-Translocation, Genetic,
pubmed-meshheading:15034568-Urinary Bladder Neoplasms
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer.
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| pubmed:affiliation |
Department of Otolaryngology, Head and Neck Surgery, Division of Head and Neck Cancer Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|