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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2004-4-1
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pubmed:abstractText |
Many human T-cell responses specific for epitopes in Plasmodium falciparum have been described, but none has yet been shown to be predictive of protection against natural malaria infection. Here we report a peptide-specific T-cell assay that is strongly associated with protection of humans in The Gambia, West Africa, from both malaria infection and disease. The assay detects interferon-gamma-secreting CD4(+) T cells specific for a conserved sequence from the circumsporozoite protein, which binds to many human leukocyte antigen (HLA)-DR types. The correlation was observed using a cultured, rather than an ex vivo, ELISPOT assay that measures central memory-'type T cells rather than activated effector T cells. These findings provide direct evidence for a protective role for CD4(+) T cells in humans, and a precise target for the design of improved vaccines against P. falciparum.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1078-8956
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pubmed:author |
pubmed-author:AkinwunmiPeterP,
pubmed-author:AllouecheAliA,
pubmed-author:BojangKalifaK,
pubmed-author:CohenJoeJ,
pubmed-author:DohertyTomT,
pubmed-author:EveraereSimoneS,
pubmed-author:GothardPhilip KPK,
pubmed-author:GreenwoodBrian MBM,
pubmed-author:HillAdrian V SAV,
pubmed-author:KesterKent EKE,
pubmed-author:McAdamKeith P W JKP,
pubmed-author:MilliganPaulP,
pubmed-author:PinderMargaretM,
pubmed-author:PlebanskiMagdalenaM,
pubmed-author:ReeceWilliam H HWH,
pubmed-author:TornieporthNadiaN,
pubmed-author:VossGeraldG,
pubmed-author:WatkinsKatherine RKR
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
406-10
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15034567-Adolescent,
pubmed-meshheading:15034567-Adult,
pubmed-meshheading:15034567-Amino Acid Sequence,
pubmed-meshheading:15034567-CD4-Positive T-Lymphocytes,
pubmed-meshheading:15034567-Conserved Sequence,
pubmed-meshheading:15034567-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:15034567-Epitopes,
pubmed-meshheading:15034567-Humans,
pubmed-meshheading:15034567-Immunologic Memory,
pubmed-meshheading:15034567-Malaria, Falciparum,
pubmed-meshheading:15034567-Middle Aged,
pubmed-meshheading:15034567-Molecular Sequence Data,
pubmed-meshheading:15034567-Protozoan Proteins
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pubmed:year |
2004
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pubmed:articleTitle |
A CD4(+) T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease.
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pubmed:affiliation |
Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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