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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2004-3-22
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pubmed:abstractText |
We studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B(*)Q0) and C3 (C3(*)F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B(*)Q0 on health or survival.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0077-8923
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
1010
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
496-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15033778-Adolescent,
pubmed-meshheading:15033778-Adult,
pubmed-meshheading:15033778-Aged,
pubmed-meshheading:15033778-Aged, 80 and over,
pubmed-meshheading:15033778-Aging,
pubmed-meshheading:15033778-Complement C3,
pubmed-meshheading:15033778-Complement C4b,
pubmed-meshheading:15033778-Complement System Proteins,
pubmed-meshheading:15033778-Gene Frequency,
pubmed-meshheading:15033778-Genetic Variation,
pubmed-meshheading:15033778-HLA-B Antigens,
pubmed-meshheading:15033778-Health Status,
pubmed-meshheading:15033778-Humans,
pubmed-meshheading:15033778-Iceland,
pubmed-meshheading:15033778-Middle Aged,
pubmed-meshheading:15033778-Survivors
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pubmed:year |
2003
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pubmed:articleTitle |
An age-associated decrease in the frequency of C4B*Q0 indicates that null alleles of complement may affect health or survival.
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pubmed:affiliation |
Department of Immunology, Institute of Laboratory Medicine and Department of Medicine, Landspítali University Hospital, LSH Hringbraut, 101 Reykjavík, Iceland. garason@landspitali.is
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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