Linked Life Data

15033463

Source:http://linkedlifedata.com/resource/pubmed/id/15033463

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-3-22
pubmed:abstractText
In order to find the effect of genetic polymorphisms of GSTM1 and GSTT1 on blood pressure of individuals chronically exposed to sulfur compounds, the present study was done. Study subjects (38 males, 38 females) were residents of contaminated areas of Masjid-i-Sulaiman (southwest of Iran). The GSTM1 and GSTT1 genotypes were determined using a polymerase chain reaction (PCR)-based method. The non-parametric Sign test was applied in order to detect differences between the GSTs genotypes of study subjects and the normal mean values according to the sex and age of subjects. From four combination of genotypes, systolic blood pressure significantly decreased in combination of null-GSTM1 and present-GSTT1 (Z=-2.41; P=0.016), and diastolic blood pressure significantly increased in combination of present-GSTM1 and null-GSTT1 (Z=+2.14; P=0.032). It is speculated about polymorphisms of GSTs in individuals chronically exposed to natural sour gas, which contains H2S, fulfilling a physiological role(s) in regulating blood pressure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
316
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
749-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Polymorphisms of glutathione S-transferase M1 and T1 modulate blood pressure of individuals chronically exposed to natural sour gas containing sulfur compounds.
pubmed:affiliation
Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran. saadat@susc.ac.ir
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't