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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-3-22
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pubmed:abstractText |
Five new beauveriolides were isolated from the acetone extracts of Beauveria sp. FO-6979 mycelia fermented in amino acid-supplemented media. The structures were elucidated by spectroscopic studies including NMR experiments and chemical degradation. All the beauveriolides are cyclodepsipeptides consisting of one 3-hydroxy-4-methyl fatty acid, two L-amino acids and one D-amino acid in common. Beauveriolide VII with the structure of cyclo-[3-hydroxy-4-methyloctanoyl-L-phenylalanyl-L-alanyl-D-valyl] inhibited lipid droplet formation and cholesteryl ester synthesis in macrophages, but the other beauveriolides showed only slight or almost no effect on lipid droplet formation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-8820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15032479-Amino Acids,
pubmed-meshheading:15032479-Animals,
pubmed-meshheading:15032479-Anti-Bacterial Agents,
pubmed-meshheading:15032479-Ascomycota,
pubmed-meshheading:15032479-Cholesterol Esters,
pubmed-meshheading:15032479-Chromatography, Gel,
pubmed-meshheading:15032479-Depsipeptides,
pubmed-meshheading:15032479-Fermentation,
pubmed-meshheading:15032479-Lipid Metabolism,
pubmed-meshheading:15032479-Macrophages, Peritoneal,
pubmed-meshheading:15032479-Mice,
pubmed-meshheading:15032479-Microbial Sensitivity Tests,
pubmed-meshheading:15032479-Molecular Structure,
pubmed-meshheading:15032479-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:15032479-Peptides, Cyclic,
pubmed-meshheading:15032479-Spectrometry, Mass, Fast Atom Bombardment,
pubmed-meshheading:15032479-Spectrophotometry, Infrared,
pubmed-meshheading:15032479-Spectrophotometry, Ultraviolet
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pubmed:year |
2004
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pubmed:articleTitle |
New beauveriolides produced by amino acid-supplemented fermentation of Beauveria sp. FO-6979.
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pubmed:affiliation |
Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, Shirokane, Minato-ku, Tokyo 108-8641, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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