Source:http://linkedlifedata.com/resource/pubmed/id/15031797
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
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umls-concept:C0030498,
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umls-concept:C0205216,
umls-concept:C0242723,
umls-concept:C0332281,
umls-concept:C0871261,
umls-concept:C1521797,
umls-concept:C1552644,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1744681,
umls-concept:C1823153,
umls-concept:C1858460,
umls-concept:C2349975,
umls-concept:C2349976,
umls-concept:C2911692
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| pubmed:issue |
7
|
| pubmed:dateCreated |
2004-3-19
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| pubmed:abstractText |
The conditions and mechanisms of congenital transmission of Trypanosoma cruzi remain largely unknown. In the present study, we compared the parasitic loads and the immune responses of pregnant T. cruzi-infected women who transmitted parasites to their fetus ("M+B+ mothers") with those of such women who did not transmit parasites to their fetus ("M+B- mothers"). M+B+ mothers had a higher frequency of positive results of hemoculture for T. cruzi than did M+B- mothers, in association with depressed production of parasite-specific interferon- gamma by blood cells that persisted after delivery. In contrast, the production of interleukin (IL)-2, IL-4, and IL-10 and transforming growth factor- beta 1 was similar between both groups of infected mothers, after stimulation with T. cruzi lysate. Flow cytometric analysis showed that T cells and monocytes of M+B+ mothers were less activated than were those of M+B- mothers. Altogether, these results indicate that congenital transmission of T. cruzi is associated with high parasitic loads and peripheral deficient immunological responses in mothers.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
0022-1899
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
189
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1274-81
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:15031797-Animals,
pubmed-meshheading:15031797-Chagas Disease,
pubmed-meshheading:15031797-Female,
pubmed-meshheading:15031797-Flow Cytometry,
pubmed-meshheading:15031797-Humans,
pubmed-meshheading:15031797-Infant, Newborn,
pubmed-meshheading:15031797-Infectious Disease Transmission, Vertical,
pubmed-meshheading:15031797-Interferon-gamma,
pubmed-meshheading:15031797-Interleukins,
pubmed-meshheading:15031797-Parasitemia,
pubmed-meshheading:15031797-Pregnancy,
pubmed-meshheading:15031797-Transforming Growth Factor beta,
pubmed-meshheading:15031797-Trypanosoma cruzi
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Congenital transmission of Trypanosoma cruzi is associated with maternal enhanced parasitemia and decreased production of interferon- gamma in response to parasite antigens.
|
| pubmed:affiliation |
Laboratoire de Parasitologie, Faculte de Medecine, Universite Libre de Bruxelles, Brussels, Belgium.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|