Source:http://linkedlifedata.com/resource/pubmed/id/15031334
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2004-3-19
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| pubmed:abstractText |
The clinical utility of cyclosporin A (CsA) has been limited by its nephrotoxicity, which is characterized by tubular atrophy, interstitial fibrosis and progressive renal impairment. Hepatocyte growth factor (HGF), which plays diverse roles in the regeneration of the kidney following acute renal failure, has been reported to protect against and salvage renal injury by acting as a renotropic and anti-fibrotic factor. Here, we investigated protective effects of HGF gene therapy on CsA-induced nephrotoxicity by using an electroporation-mediated gene transfer method.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
|
| pubmed:issn |
0931-0509
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
812-6
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| pubmed:meshHeading |
pubmed-meshheading:15031334-Animals,
pubmed-meshheading:15031334-Cyclosporine,
pubmed-meshheading:15031334-Gene Therapy,
pubmed-meshheading:15031334-Gene Transfer Techniques,
pubmed-meshheading:15031334-Hepatocyte Growth Factor,
pubmed-meshheading:15031334-Kidney,
pubmed-meshheading:15031334-Kidney Diseases,
pubmed-meshheading:15031334-Male,
pubmed-meshheading:15031334-Rats,
pubmed-meshheading:15031334-Rats, Sprague-Dawley
|
| pubmed:year |
2004
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| pubmed:articleTitle |
Direct transfer of hepatocyte growth factor gene into kidney suppresses cyclosporin A nephrotoxicity in rats.
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| pubmed:affiliation |
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan. isaka@medone.med.osaka-u.ac.jp
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| pubmed:publicationType |
Journal Article
|