Linked Life Data

15028529

Source:http://linkedlifedata.com/resource/pubmed/id/15028529

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-3-18
pubmed:abstractText
Transgenic and knockout models have been used successfully in order to attribute specific functions to distinct growth factors. However, it is not clear which from the different IGF-components are actually altered when growth is affected. Furthermore it is not clear if unique or redundant patterns of IGF-component expression are present under conditions of elevated or reduced growth. To address these questions we have used a unique set of mouse models generated by divergent selection for high and low body growth. The set of mouse models consisted of eight mouse lines established in different laboratories. We have studied systemic and local expression of growth relevant genes in these mouse lines highly diverging for body and carcass weights but also for nose-rump lengths. As a strictly conserved pattern, serum IGF-I levels were dramatically increased in all H-lines if compared with the respective L-lines. By contrast serum IGFBP concentrations did not reveal clear patterns of expression in response to growth selection: IGFBP-3 was elevated in some H-lines, IGFBP-2 was increased in H- or L-lines and IGFBP-4 was similar in H- and L-lines. The fact that IGFBP-2 was the only IGFBP elevated in part of the L-lines, identifies IGFBP-2 as an exclusive although facultative negative effector for growth in the circulation among all other IGFBPs. In muscle tissue from selected breeding groups characterized by specific increases of the carcass weights we found redundant patterns of gene expression indicating the absence of tissue-specific or uniquely fixed expression patterns during growth selection within muscle tissue. The finding that serum but not tissue IGF-I levels were strictly positively correlated with growth during growth selection argues for an important role of endocrine IGF-I for postnatal growth in mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0016-6480
pubmed:author
pubmed:issnType
Print
pubmed:volume
136
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
248-59
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15028529-Animals, pubmed-meshheading:15028529-Body Weight, pubmed-meshheading:15028529-Gene Expression, pubmed-meshheading:15028529-Growth, pubmed-meshheading:15028529-Insulin-Like Growth Factor Binding Protein 2, pubmed-meshheading:15028529-Insulin-Like Growth Factor Binding Protein 3, pubmed-meshheading:15028529-Insulin-Like Growth Factor Binding Protein 4, pubmed-meshheading:15028529-Insulin-Like Growth Factor I, pubmed-meshheading:15028529-Insulin-Like Growth Factor II, pubmed-meshheading:15028529-Male, pubmed-meshheading:15028529-Mice, pubmed-meshheading:15028529-Mice, Knockout, pubmed-meshheading:15028529-Mice, Transgenic, pubmed-meshheading:15028529-Muscle, Skeletal, pubmed-meshheading:15028529-RNA, Messenger, pubmed-meshheading:15028529-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:15028529-Selection, Genetic, pubmed-meshheading:15028529-Somatomedins
pubmed:year
2004
pubmed:articleTitle
Growth selection in mice reveals conserved and redundant expression patterns of the insulin-like growth factor system.
pubmed:affiliation
Lehrstuhl für Molekulare Tierzucht und Biotechnologie/Genzentrum, Ludwig-Maximilians-Universität, 81377 Munich, Germany. hoeflich@lmb.uni-muenchen.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't