| pubmed-article:15026362 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15026362 | lifeskim:mentions | umls-concept:C0025202 | lld:lifeskim |
| pubmed-article:15026362 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:15026362 | lifeskim:mentions | umls-concept:C1522484 | lld:lifeskim |
| pubmed-article:15026362 | lifeskim:mentions | umls-concept:C0036525 | lld:lifeskim |
| pubmed-article:15026362 | lifeskim:mentions | umls-concept:C0475445 | lld:lifeskim |
| pubmed-article:15026362 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:15026362 | lifeskim:mentions | umls-concept:C1516031 | lld:lifeskim |
| pubmed-article:15026362 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:15026362 | lifeskim:mentions | umls-concept:C0205221 | lld:lifeskim |
| pubmed-article:15026362 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15026362 | pubmed:dateCreated | 2004-3-17 | lld:pubmed |
| pubmed-article:15026362 | pubmed:abstractText | The clinical relevance of dendritic cells (DCs) at the tumor site remains a matter of debate concerning their role in the generation of effective antitumor immunity in human cancers. We performed a comprehensive immunohistochemical analysis using a panel of DC-specific antibodies on regressing tumor lesions and sentinel lymph nodes (SLNs) in melanoma patients. Here we show in a case report involving spontaneous regression of metastatic melanoma that the accumulation of DC-Lamp+ DCs, clustered with tumor cells and lymphocytes, is associated with local expansion of antigen-specific memory effector CTLs. These findings were extended in a series of 19 melanoma-positive SLNs and demonstrated a significant correlation between the density of DC-Lamp+ DC infiltrates in SLNs with the absence of metastasis in downstream lymph nodes. This study, albeit performed in a limited series of patients, points to a pivotal role of mature DCs in the local expansion of efficient antitumor T-cell-mediated immune responses at the initial sites of metastasis and may have important implications regarding the prognosis, staging, and immunotherapy of melanoma patients. | lld:pubmed |
| pubmed-article:15026362 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15026362 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15026362 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15026362 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15026362 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15026362 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15026362 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15026362 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15026362 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15026362 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15026362 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15026362 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15026362 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15026362 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15026362 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15026362 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:15026362 | pubmed:author | pubmed-author:AvrilMarie-Fr... | lld:pubmed |
| pubmed-article:15026362 | pubmed:author | pubmed-author:LebecqueSerge... | lld:pubmed |
| pubmed-article:15026362 | pubmed:author | pubmed-author:RimoldiDonata... | lld:pubmed |
| pubmed-article:15026362 | pubmed:author | pubmed-author:RomeroPedroP | lld:pubmed |
| pubmed-article:15026362 | pubmed:author | pubmed-author:RobertCarolin... | lld:pubmed |
| pubmed-article:15026362 | pubmed:author | pubmed-author:ZitvogelLaure... | lld:pubmed |
| pubmed-article:15026362 | pubmed:author | pubmed-author:SpatzAlainA | lld:pubmed |
| pubmed-article:15026362 | pubmed:author | pubmed-author:FerradiniLaur... | lld:pubmed |
| pubmed-article:15026362 | pubmed:author | pubmed-author:AngevinEricE | lld:pubmed |
| pubmed-article:15026362 | pubmed:author | pubmed-author:MovassaghMojg... | lld:pubmed |
| pubmed-article:15026362 | pubmed:author | pubmed-author:DavoustJeanJ | lld:pubmed |
| pubmed-article:15026362 | pubmed:author | pubmed-author:PittetMikaëlM | lld:pubmed |
| pubmed-article:15026362 | pubmed:author | pubmed-author:LiénardDanièl... | lld:pubmed |
| pubmed-article:15026362 | pubmed:author | pubmed-author:GugerliOliver... | lld:pubmed |
| pubmed-article:15026362 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15026362 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15026362 | pubmed:volume | 64 | lld:pubmed |
| pubmed-article:15026362 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15026362 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15026362 | pubmed:pagination | 2192-8 | lld:pubmed |
| pubmed-article:15026362 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:15026362 | pubmed:meshHeading | pubmed-meshheading:15026362... | lld:pubmed |
| pubmed-article:15026362 | pubmed:meshHeading | pubmed-meshheading:15026362... | lld:pubmed |
| pubmed-article:15026362 | pubmed:meshHeading | pubmed-meshheading:15026362... | lld:pubmed |
| pubmed-article:15026362 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15026362 | pubmed:articleTitle | Selective accumulation of mature DC-Lamp+ dendritic cells in tumor sites is associated with efficient T-cell-mediated antitumor response and control of metastatic dissemination in melanoma. | lld:pubmed |
| pubmed-article:15026362 | pubmed:affiliation | Immunology/Institut National de la Santé et de la Recherche Médicale ERM0208 and Immunotherapy Unit, Department of Pathology, Dermatology Unit, Institut Gustave-Roussy, 94805 Villejuif Cedex, France. | lld:pubmed |
| pubmed-article:15026362 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15026362 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15026362 | pubmed:publicationType | Case Reports | lld:pubmed |
| pubmed-article:15026362 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15026362 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15026362 | lld:pubmed |
