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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2004-3-17
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pubmed:abstractText |
The clinical relevance of dendritic cells (DCs) at the tumor site remains a matter of debate concerning their role in the generation of effective antitumor immunity in human cancers. We performed a comprehensive immunohistochemical analysis using a panel of DC-specific antibodies on regressing tumor lesions and sentinel lymph nodes (SLNs) in melanoma patients. Here we show in a case report involving spontaneous regression of metastatic melanoma that the accumulation of DC-Lamp+ DCs, clustered with tumor cells and lymphocytes, is associated with local expansion of antigen-specific memory effector CTLs. These findings were extended in a series of 19 melanoma-positive SLNs and demonstrated a significant correlation between the density of DC-Lamp+ DC infiltrates in SLNs with the absence of metastasis in downstream lymph nodes. This study, albeit performed in a limited series of patients, points to a pivotal role of mature DCs in the local expansion of efficient antitumor T-cell-mediated immune responses at the initial sites of metastasis and may have important implications regarding the prognosis, staging, and immunotherapy of melanoma patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/CCR6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CCR7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Lysosome-Associated Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/MART-1 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/MLANA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR6,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR7,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0008-5472
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pubmed:author |
pubmed-author:AngevinEricE,
pubmed-author:AvrilMarie-FrançoiseMF,
pubmed-author:DavoustJeanJ,
pubmed-author:FerradiniLaurentL,
pubmed-author:GugerliOliverO,
pubmed-author:LebecqueSergeS,
pubmed-author:LiénardDanièleD,
pubmed-author:MovassaghMojganM,
pubmed-author:PittetMikaëlM,
pubmed-author:RimoldiDonataD,
pubmed-author:RobertCarolineC,
pubmed-author:RomeroPedroP,
pubmed-author:SpatzAlainA,
pubmed-author:ZitvogelLaurenceL
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2192-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15026362-Adult,
pubmed-meshheading:15026362-Antigens, CD,
pubmed-meshheading:15026362-Antigens, Neoplasm,
pubmed-meshheading:15026362-Dendritic Cells,
pubmed-meshheading:15026362-Humans,
pubmed-meshheading:15026362-Immunophenotyping,
pubmed-meshheading:15026362-Ligands,
pubmed-meshheading:15026362-Lymph Nodes,
pubmed-meshheading:15026362-Lymphatic Metastasis,
pubmed-meshheading:15026362-Lymphocytes, Tumor-Infiltrating,
pubmed-meshheading:15026362-Lysosome-Associated Membrane Glycoproteins,
pubmed-meshheading:15026362-MART-1 Antigen,
pubmed-meshheading:15026362-Male,
pubmed-meshheading:15026362-Melanoma,
pubmed-meshheading:15026362-Neoplasm Proteins,
pubmed-meshheading:15026362-Receptors, CCR6,
pubmed-meshheading:15026362-Receptors, CCR7,
pubmed-meshheading:15026362-Receptors, Chemokine,
pubmed-meshheading:15026362-Sentinel Lymph Node Biopsy,
pubmed-meshheading:15026362-Skin Neoplasms,
pubmed-meshheading:15026362-T-Lymphocytes, Cytotoxic
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pubmed:year |
2004
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pubmed:articleTitle |
Selective accumulation of mature DC-Lamp+ dendritic cells in tumor sites is associated with efficient T-cell-mediated antitumor response and control of metastatic dissemination in melanoma.
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pubmed:affiliation |
Immunology/Institut National de la Santé et de la Recherche Médicale ERM0208 and Immunotherapy Unit, Department of Pathology, Dermatology Unit, Institut Gustave-Roussy, 94805 Villejuif Cedex, France.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Case Reports,
Research Support, Non-U.S. Gov't
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