Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-6-21
pubmed:abstractText
Quebec platelet disorder (QPD) is an autosomal dominant bleeding disorder associated with increased urokinase-type plasminogen activator in platelets and alpha-granule protein degradation. To determine bleeding risks and common manifestations of QPD, a history questionnaire was developed and administered to 127 relatives in a family with QPD. Data entry was done blinded to affected and unaffected status, determined by assays for platelet urokinase-type plasminogen activator (u-PA) and fibrinogen degradation. Odds ratios (ORs), with 95% confidence intervals (CIs), were determined for items queried. Summative bleeding scores for each individual were calculated using items with OR more than 1. Mean ages (34 years; range, 1-89 years) were similar for affected (n = 23) and unaffected (n = 104) family members. Affected individuals had higher mean bleeding scores (P <.0001) and a much higher likelihood (OR > 20) of having bleeding that led to lifestyle changes, bruises that spread lower or as large or larger than an orange or both, joint bleeds, bleeding longer than 24 hours after dental extractions or deep cuts, and received or been recommended other treatments (fibrinolytic inhibitors) for bleeding. Individuals with QPD and exposure(s) to hemostatic challenges had experienced excessive bleeding only when fibrinolytic inhibitors had not been used. These data illustrate that QPD is associated with increased risks of bleeding that can be modified by fibrinolytic inhibitors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
159-65
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15026313-Adolescent, pubmed-meshheading:15026313-Adult, pubmed-meshheading:15026313-Aged, pubmed-meshheading:15026313-Aged, 80 and over, pubmed-meshheading:15026313-Blood Platelet Disorders, pubmed-meshheading:15026313-Cardiovascular Diseases, pubmed-meshheading:15026313-Child, pubmed-meshheading:15026313-Child, Preschool, pubmed-meshheading:15026313-Confidence Intervals, pubmed-meshheading:15026313-Family, pubmed-meshheading:15026313-Female, pubmed-meshheading:15026313-Genes, Dominant, pubmed-meshheading:15026313-Hemorrhage, pubmed-meshheading:15026313-Humans, pubmed-meshheading:15026313-Infant, pubmed-meshheading:15026313-Male, pubmed-meshheading:15026313-Middle Aged, pubmed-meshheading:15026313-Pedigree, pubmed-meshheading:15026313-Questionnaires, pubmed-meshheading:15026313-Risk Factors, pubmed-meshheading:15026313-Sex Factors
pubmed:year
2004
pubmed:articleTitle
Bleeding risks associated with inheritance of the Quebec platelet disorder.
pubmed:affiliation
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't