Source:http://linkedlifedata.com/resource/pubmed/id/15026056
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2004-3-17
|
| pubmed:abstractText |
High-throughput screening of two million compounds in 37 distinct encoded combinatorial libraries using FSH receptor transfected cells provided small molecule agonists such as 1 (EC(50)=3 microM) and 2 (EC(50)=3.9 microM), based on which a focused combinatorial library with a total of 31372 compounds was designed, synthesized, and screened to reveal 72 novel biaryl FSH receptor agonists such as 8a-c as well as a unique combinatorial SAR.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0960-894X
|
| pubmed:author |
pubmed-author:AdangAnton E PAE,
pubmed-author:DolleRoland ERE,
pubmed-author:DongGuizhenG,
pubmed-author:FitzpatrickDanD,
pubmed-author:GuoTaoT,
pubmed-author:HoKoc-KanKK,
pubmed-author:KultgenSteven GSG,
pubmed-author:LiuRuiyanR,
pubmed-author:McDonaldEdwardE,
pubmed-author:McGuinnessBrian FBF,
pubmed-author:PengGengG,
pubmed-author:SaionzKurt WKW,
pubmed-author:TURJ JJJ,
pubmed-author:ValenzanoKenneth JKJ,
pubmed-author:WebbMaria LML,
pubmed-author:van StratenNicole C RNC
|
| pubmed:issnType |
Print
|
| pubmed:day |
5
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1713-6
|
| pubmed:meshHeading | |
| pubmed:year |
2004
|
| pubmed:articleTitle |
Small molecule biaryl FSH receptor agonists. Part 1: Lead discovery via encoded combinatorial synthesis.
|
| pubmed:affiliation |
Pharmacopeia, Inc, PO Box 5350, Princeton, NJ 08543-5350, USA.tguo@pharmcop.com
|
| pubmed:publicationType |
Journal Article
|