|
rdf:type |
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lifeskim:mentions |
umls-concept:C0002520,
umls-concept:C0026377,
umls-concept:C0030956,
umls-concept:C0037949,
umls-concept:C0053048,
umls-concept:C0056209,
umls-concept:C0205214,
umls-concept:C0449830,
umls-concept:C1280500,
umls-concept:C1705493,
umls-concept:C1883254,
umls-concept:C2603343,
umls-concept:C2827597
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|
pubmed:issue |
7
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pubmed:dateCreated |
2004-3-17
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pubmed:abstractText |
The synthesis and structural analysis, involving X-ray crystallographic, nuclear magnetic resonance, and computational studies of four diastereomers of the common western BCD diarylether macrocycle of the complestatins, a family of HIV entry inhibitors, has been achieved exploiting a ruthenium-promoted intramolecular S(N)Ar reaction. The stereogenicity of the individual phenylglycines (residues C and D) results in remarkable effects on the backbone conformation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
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pubmed:month |
Apr
|
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pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
5
|
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pubmed:volume |
14
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
1697-702
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
|
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pubmed:year |
2004
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pubmed:articleTitle |
Complestatin synthetic studies; the effect of the amino acid configuration on peptide backbone conformation in the common western BCD macrocycle.
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|
pubmed:affiliation |
Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6323, USA. smithab@sas.upenn.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
