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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-3-17
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pubmed:abstractText |
Chronic periodontitis is an inflammatory disease, which is a major cause of tooth loss. The proinflammatory cytokines interleukin-1 (IL-1) and interleukin-6 (IL-6) are key regulators of the host response to microbial infection and major modulators of extracellular matrix catabolism and bone resorption. The purpose of this study was to investigate the associations of chronic periodontitis with IL-6 gene polymorphisms (at positions -597 [G/A], -572 [G/C], and -174 [G/C]).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-3492
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
30-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15025214-Adult,
pubmed-meshheading:15025214-Alleles,
pubmed-meshheading:15025214-Case-Control Studies,
pubmed-meshheading:15025214-Chronic Disease,
pubmed-meshheading:15025214-Female,
pubmed-meshheading:15025214-Gene Frequency,
pubmed-meshheading:15025214-Genetic Predisposition to Disease,
pubmed-meshheading:15025214-Heterozygote,
pubmed-meshheading:15025214-Humans,
pubmed-meshheading:15025214-Interleukin-6,
pubmed-meshheading:15025214-Male,
pubmed-meshheading:15025214-Middle Aged,
pubmed-meshheading:15025214-Monte Carlo Method,
pubmed-meshheading:15025214-Odds Ratio,
pubmed-meshheading:15025214-Periodontitis,
pubmed-meshheading:15025214-Polymerase Chain Reaction,
pubmed-meshheading:15025214-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:15025214-Promoter Regions, Genetic,
pubmed-meshheading:15025214-Smoking
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pubmed:year |
2004
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pubmed:articleTitle |
Analysis of the interleukin-6 gene promoter polymorphisms in Czech patients with chronic periodontitis.
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pubmed:affiliation |
Department of Pathological Physiology, Medical Faculty, Masaryk University, Brno, Czech Republic. holla@med.muni.cz
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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