pubmed:abstractText |
Apart from allergic mechanisms, a lack or mutation of metabolic enzymes may cause adverse drug reactions. Patch testing has rarely been useful in cutaneous adverse drug reactions (CADRs) induced by diphenylhydantoin (DPH). Genetic polymorphisms leading to altered metabolic processes of cytochrome P(450) (CYP) 2C9, a main metabolic enzyme for DPH, may be the pathological mechanism for certain cases of DPH-induced CADRs.
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pubmed:affiliation |
Department of Dermatology, Eulji Hospital, Eulji University School of Medicine, 280-1 Hagye-1-dong, Nowon-gu, 139-711 Seoul, South Korea. lay5103@eulji.or.kr
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