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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1978-9-29
|
| pubmed:abstractText |
The metabolic clearance rates (MCR), conversion ratios (C), interconversion (rho), production rates (PR), secretion rates (SR), and relative contributions of maternal dehydroepiandrosterone (D) and D-sulfate (DS) to serum estradiol (E2) were determined in five pregnant baboons (Papio papio; 154-167 days gestation, term = 184 days) by constant intravenous infusion of [3H]DS and [14C]D. MCR-D (mean +/- SE) was greater (39.2 +/- 3.3 1/day.kg, P less than 0.001) than MCR-DS (3.1 +/- 0.3 1/day.kg). Because C-D leads to DS (5.460 +/- 0.461) exceeded (P less than 0.001) C-DS leads to (0.006 +/- 0.001), rho-DS leads to DS was greater (42.5% +/- 3.0%, P less than 0.001) than rho-DS leads to D (7.8 +/- 1.0%). C-D leads to E2 was greater (0.256 +/- 0.040) than C-DS leads to E2 (0.002 +/- 0.000). Using these values and serum levels of D (2.46 microgram/100 ml) and DS (18.9 microgram/100 ml) reported previously, SR and PR of D and DS were calculated. Of the total D produced (11.5 microgram/min), 98% was secreted, whereas only 32% of DS produced (7.1 microgram/min) was due to secretion. Using the serum D and DS levels and their conversion to E2, it was calculated that 89.7% of serum E2 was formed directly from D, 4.4% from D via DS, 1.8% from DS directly, and 4.1% from DS via D. It is concluded that, in spite of the low serum D level resulting from a high MCR, the large SR-D and more efficient conversion of D to E2 makes D, and not DS, the major circulating estrogen precursor in late baboon pregnancy.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0002-9513
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
235
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
E78-81
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:150235-Animals,
pubmed-meshheading:150235-Dehydroepiandrosterone,
pubmed-meshheading:150235-Estradiol,
pubmed-meshheading:150235-Female,
pubmed-meshheading:150235-Infusions, Parenteral,
pubmed-meshheading:150235-Metabolic Clearance Rate,
pubmed-meshheading:150235-Papio,
pubmed-meshheading:150235-Pregnancy,
pubmed-meshheading:150235-Pregnancy, Animal,
pubmed-meshheading:150235-Sulfuric Acids
|
| pubmed:year |
1978
|
| pubmed:articleTitle |
Contribution of dehydroepiandrosterone and its sulfate to estradiol in baboon pregnancy.
|
| pubmed:publicationType |
Journal Article
|