Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 1
pubmed:dateCreated
2004-5-11
pubmed:abstractText
We have previously demonstrated that trinitrobenzene sulphonic acid (TNBS)-induced colitis in guinea pig is associated with hyperexcitability of myenteric AH neurones, enhanced synaptic activity in the myenteric plexus, increased serotonin (5-HT) availability in the mucosa, and decreased propulsive motor activity. The current study tested the hypothesis that the activation of cyclooxygenase (COX) contributes to these alterations in bowel functions. DFU inhibition of COX-2, but not SC-560 inhibition of COX-1, restored to normal levels the electrical properties of myenteric AH neurones, the proportion of S neurones exhibiting slow EPSPs, and the rate of propulsive motor activity. Neither inhibitor was effective in altering the level of inflammation, the increased availability of mucosal 5-HT, or the enhanced fast EPSPs in myenteric AH and S neurones. COX-2 expression is enhanced in the myenteric plexus and cells within the smooth muscle layers during colitis, possibly reflecting the site at which COX-2 inhibition acts to allow recovery of motor function. In support of this concept, COX-1, but not COX-2, inhibition was effective in restoring normal mucosal prostaglandin levels. These results indicate that the various changes that occur in the motor neural pathways of the distal colon in TNBS-induced colitis do not involve a single neuroimmune mechanism. COX-2 activation is a critical step in the enhanced excitability of AH neurones as well as diminished propulsive motility in TNBS colitis, whereas other yet to be resolved pathways, that do not involve COX-1 or COX-2 activation, lead to altered 5-HT content in the mucosa and an augmentation of fast EPSPs.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-10323306, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-10327390, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-10332100, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-10426313, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-10436856, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-10844098, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-11052985, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-11076873, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-11104339, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-11146429, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-11264251, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-11503144, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-11729115, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-11984529, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-12388180, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-12388206, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-12562910, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-12631664, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-12646422, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-1280933, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-12823157, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-1309357, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-1694171, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-1970708, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-2158882, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-2535830, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-2831015, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-2900605, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-3354674, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-4383761, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-6319219, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-7636031, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-7797026, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-7810655, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-8027515, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-8027516, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-8304452, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-8419261, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-8430807, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-8536163, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-8638704, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-8903327, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-9026781, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-9146894, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-9406116, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-9435560, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-9460790, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-9679035, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-9737710, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-9773924, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-9789085, http://linkedlifedata.com/resource/pubmed/commentcorrection/15020692-9815020
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-3751
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
557
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
191-205
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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