Linked Life Data

15019940

Source:http://linkedlifedata.com/resource/pubmed/id/15019940

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-3-15
pubmed:abstractText
During lamination of the cerebellar cortex, granule cells initially migrate tangentially along the external granule layer, and then make a vertical turn and migrate radially to the internal granule layer. We comparatively analyzed the properties of biphasic migration of granule cells in a microexplant culture in which quantitation of morphology and subcellular localization of molecules were readily accomplished. Tangential migration was guided by a leading process that later formed a parallel fiber axon. Translocation of the soma within the axonal process occurred independently of the rapid displacement of the large growth cone. On the other hand, radial migration was guided by a leading process that differentiated into a dendrite after completion of migration. Displacement of the soma and the tiny growth cone were linked so that the radial leading process adopted locomotion and kept a constant length. We propose that the dual phases of granule cell migration are achieved by distinct cellular mechanisms guided by the leading processes forming an axon and a dendrite, respectively.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1044-7431
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
228-40
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Dual phases of migration of cerebellar granule cells guided by axonal and dendritic leading processes.
pubmed:affiliation
Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't