Source:http://linkedlifedata.com/resource/pubmed/id/15019877
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2004-3-15
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| pubmed:abstractText |
In Duchenne's muscular dystrophy (DMD), cardiac function deteriorates with time and heart failure is one of the major causes of death. The aim of the study was to determine if a decrease in the ventricular inotropic reserves could be an early sign of cardiac dysfunction in these children. Nineteen children with DMD (aged 9 to 18 years, mean age 13.6 +/- 2.4) underwent equilibrium radionuclide angiography at rest and during an inotropic stimulation with low-dose dobutamine perfusion (7.5 to 15 microg. kg(-1). min(-1)). In all patients, this investigation was short (<30 minutes), successful, and uncomplicated. At rest, left ventricular (LV) ejection fraction (EF) was normal (>0.50) in 79% of patients, and right ventricular (RV) EF was normal (>0.45) in 95%. There was a trend toward a decrease with age for rest LVEF (p = 0.051) but not for rest RVEF (p = 0.8). By contrast, marked declines with age could be documented for the increases (Delta) in LVEF and RVEF during dobutamine perfusion (p = 0.002 for DeltaLVEF and p = 0.015 for DeltaRVEF). Thus, by multivariate analysis, the sole best indicator of decline in cardiac function with age was LVEF determined with dobutamine. In children with DMD, low-dose dobutamine radionuclide angiography gives evidence of an early decline with age of the inotropic reserves of both ventricles.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0002-9149
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
15
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| pubmed:volume |
93
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
724-7
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:15019877-Adolescent,
pubmed-meshheading:15019877-Child,
pubmed-meshheading:15019877-Dobutamine,
pubmed-meshheading:15019877-Female,
pubmed-meshheading:15019877-Humans,
pubmed-meshheading:15019877-Male,
pubmed-meshheading:15019877-Muscular Dystrophy, Duchenne,
pubmed-meshheading:15019877-Radionuclide Ventriculography,
pubmed-meshheading:15019877-Retrospective Studies,
pubmed-meshheading:15019877-Ventricular Dysfunction, Left
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| pubmed:year |
2004
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| pubmed:articleTitle |
Evidence of early impairments in both right and left ventricular inotropic reserves in children with Duchenne's muscular dystrophy.
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| pubmed:affiliation |
Department of Pediatric Cardiology, Chu-Nancy, France. g.bosser@chu-nancy.fr
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| pubmed:publicationType |
Journal Article
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