Source:http://linkedlifedata.com/resource/pubmed/id/15019574
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
2004-3-15
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pubmed:abstractText |
The two inducible enzymes, manganese superoxide dismutase (MnSOD) and heme-oxygenase-1 (HO-1) may participate in the cellular defense of brain endothelium against oxidative stress. The time-dependent expression of MnSOD and HO-1 mRNAs and proteins was investigated in vitro in rat cerebral endothelial cells (CEC) subjected to sublethal mild or moderate hydroxyl radical-induced oxidative stress. Mild oxidative stress induced increases in both MnSOD and HO-1 mRNA and protein expression. Moderate oxidative stress resulted in a significant reduction in HO-1 mRNA and protein expression, whereas MnSOD expression pattern was similar to that observed after mild oxidative stress. A profound protein loss of both MnSOD and HO-1 was detected 24 h after exposure of CEC to a moderate oxidative stress. The data indicate that cerebral endothelial cells respond by increasing the expression of antioxidant defense enzymes in a manner dependent on the oxidative stress intensity.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0006-8993
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
1003
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
151-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15019574-Animals,
pubmed-meshheading:15019574-Cells, Cultured,
pubmed-meshheading:15019574-Cerebral Cortex,
pubmed-meshheading:15019574-Endothelial Cells,
pubmed-meshheading:15019574-Endothelium, Vascular,
pubmed-meshheading:15019574-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:15019574-Heme Oxygenase (Decyclizing),
pubmed-meshheading:15019574-Heme Oxygenase-1,
pubmed-meshheading:15019574-Iron Compounds,
pubmed-meshheading:15019574-Oxidative Stress,
pubmed-meshheading:15019574-Rats,
pubmed-meshheading:15019574-Superoxide Dismutase
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pubmed:year |
2004
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pubmed:articleTitle |
Differential MnSOD and HO-1 expression in cerebral endothelial cells in response to sublethal oxidative stress.
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pubmed:affiliation |
Laboratoire de Pharmacodynamie et Physiologie pharmaceutique, 7 bld Jeanne d'Arc, BP 87900, 21079 Dijon Cedex, France.
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pubmed:publicationType |
Journal Article,
Comparative Study
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