| pubmed-article:15019159 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15019159 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:15019159 | lifeskim:mentions | umls-concept:C0152035 | lld:lifeskim |
| pubmed-article:15019159 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:15019159 | lifeskim:mentions | umls-concept:C0024623 | lld:lifeskim |
| pubmed-article:15019159 | lifeskim:mentions | umls-concept:C1337032 | lld:lifeskim |
| pubmed-article:15019159 | lifeskim:mentions | umls-concept:C1333237 | lld:lifeskim |
| pubmed-article:15019159 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:15019159 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15019159 | pubmed:dateCreated | 2004-3-15 | lld:pubmed |
| pubmed-article:15019159 | pubmed:abstractText | Mammalian cells are constantly exposed to a wide variety of genotoxic agents from both endogenous and exogenous sources. Genetic variability in DNA repair may contribute to human cancer risk. In this population-based case-control study in China, we tested the hypothesis that a C to T variant (Thr241Met) of DNA repair gene XRCC3 (X-ray repair cross-complementing group 3) is associated with risk of developing gastric cancer. We genotyped for this variant using polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) in 188 histologically confirmed gastric cancer patients and 166 frequency-matched cancer-free controls. The XRCC3 genotype and allele frequencies were not significantly different between cases and controls (P = 0.99 for genotype; P = 0.76 for allele). The XRCC3 241Met allele frequency (4.8%) was significantly lower in healthy Chinese controls than previously reported healthy US Caucasian controls (38.9%). Compared with the XRCC3 241Thr/Thr genotype, the variant XRCC3241Thr/Met and Met/Met genotypes were not associated with an increased risk of gastric cancer (adjusted odds ratio (OR(a)), 1.06; 95% confidence interval (CI), 0.52-2.16). These findings suggest that polymorphisms of XRCC3 Thr241Met may not play a role in the etiology of gastric cancer. Further studies with a larger number of subjects and simultaneous measurement of different polymorphisms in DNA repair genes in the same pathway are needed to confirm these findings. | lld:pubmed |
| pubmed-article:15019159 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15019159 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15019159 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15019159 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15019159 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15019159 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15019159 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15019159 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15019159 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15019159 | pubmed:issn | 0304-3835 | lld:pubmed |
| pubmed-article:15019159 | pubmed:author | pubmed-author:KouM TMT | lld:pubmed |
| pubmed-article:15019159 | pubmed:author | pubmed-author:ZhangZhengdon... | lld:pubmed |
| pubmed-article:15019159 | pubmed:author | pubmed-author:GuoJiantaoJ | lld:pubmed |
| pubmed-article:15019159 | pubmed:author | pubmed-author:ShenHongbingH | lld:pubmed |
| pubmed-article:15019159 | pubmed:author | pubmed-author:WeiQingyiQ | lld:pubmed |
| pubmed-article:15019159 | pubmed:author | pubmed-author:WangXinruX | lld:pubmed |
| pubmed-article:15019159 | pubmed:author | pubmed-author:XuYaochuY | lld:pubmed |
| pubmed-article:15019159 | pubmed:author | pubmed-author:HuZhibinZ | lld:pubmed |
| pubmed-article:15019159 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15019159 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:15019159 | pubmed:volume | 206 | lld:pubmed |
| pubmed-article:15019159 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15019159 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15019159 | pubmed:pagination | 51-8 | lld:pubmed |
| pubmed-article:15019159 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:15019159 | pubmed:meshHeading | pubmed-meshheading:15019159... | lld:pubmed |
| pubmed-article:15019159 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15019159 | pubmed:articleTitle | Polymorphisms of DNA repair gene XRCC3 Thr241Met and risk of gastric cancer in a Chinese population. | lld:pubmed |
| pubmed-article:15019159 | pubmed:affiliation | Department of Epidemiology and Statistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China. hbshen@njmu.edu.cn | lld:pubmed |
| pubmed-article:15019159 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15019159 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15019159 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15019159 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:7517 | entrezgene:pubmed | pubmed-article:15019159 | lld:entrezgene |
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