Source:http://linkedlifedata.com/resource/pubmed/id/15019159
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2004-3-15
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| pubmed:abstractText |
Mammalian cells are constantly exposed to a wide variety of genotoxic agents from both endogenous and exogenous sources. Genetic variability in DNA repair may contribute to human cancer risk. In this population-based case-control study in China, we tested the hypothesis that a C to T variant (Thr241Met) of DNA repair gene XRCC3 (X-ray repair cross-complementing group 3) is associated with risk of developing gastric cancer. We genotyped for this variant using polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) in 188 histologically confirmed gastric cancer patients and 166 frequency-matched cancer-free controls. The XRCC3 genotype and allele frequencies were not significantly different between cases and controls (P = 0.99 for genotype; P = 0.76 for allele). The XRCC3 241Met allele frequency (4.8%) was significantly lower in healthy Chinese controls than previously reported healthy US Caucasian controls (38.9%). Compared with the XRCC3 241Thr/Thr genotype, the variant XRCC3241Thr/Met and Met/Met genotypes were not associated with an increased risk of gastric cancer (adjusted odds ratio (OR(a)), 1.06; 95% confidence interval (CI), 0.52-2.16). These findings suggest that polymorphisms of XRCC3 Thr241Met may not play a role in the etiology of gastric cancer. Further studies with a larger number of subjects and simultaneous measurement of different polymorphisms in DNA repair genes in the same pathway are needed to confirm these findings.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0304-3835
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
31
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| pubmed:volume |
206
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
51-8
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:15019159-Adenocarcinoma,
pubmed-meshheading:15019159-Adult,
pubmed-meshheading:15019159-Aged,
pubmed-meshheading:15019159-Aged, 80 and over,
pubmed-meshheading:15019159-Case-Control Studies,
pubmed-meshheading:15019159-China,
pubmed-meshheading:15019159-DNA, Neoplasm,
pubmed-meshheading:15019159-DNA Repair,
pubmed-meshheading:15019159-DNA-Binding Proteins,
pubmed-meshheading:15019159-Female,
pubmed-meshheading:15019159-Genetic Predisposition to Disease,
pubmed-meshheading:15019159-Genetic Variation,
pubmed-meshheading:15019159-Genotype,
pubmed-meshheading:15019159-Humans,
pubmed-meshheading:15019159-Male,
pubmed-meshheading:15019159-Middle Aged,
pubmed-meshheading:15019159-Polymerase Chain Reaction,
pubmed-meshheading:15019159-Polymorphism, Genetic,
pubmed-meshheading:15019159-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:15019159-Risk Factors,
pubmed-meshheading:15019159-Stomach Neoplasms
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| pubmed:year |
2004
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| pubmed:articleTitle |
Polymorphisms of DNA repair gene XRCC3 Thr241Met and risk of gastric cancer in a Chinese population.
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| pubmed:affiliation |
Department of Epidemiology and Statistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China. hbshen@njmu.edu.cn
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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