| pubmed-article:15018667 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15018667 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:15018667 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:15018667 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:15018667 | lifeskim:mentions | umls-concept:C0242656 | lld:lifeskim |
| pubmed-article:15018667 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:15018667 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:15018667 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:15018667 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15018667 | pubmed:dateCreated | 2004-3-15 | lld:pubmed |
| pubmed-article:15018667 | pubmed:abstractText | Transforming growth factor-beta(1) (TGF-beta(1)) is a pleiotropic cytokine with a variety of effects on a wide range of cells in the immune system. Evidence suggests that TGF-beta(1) is also involved in the pathogenesis of human immunodeficiency virus type 1 infections. The aim of this study was to explore possible relationships between circulating TGF-beta(1) and immune as well as clinical HIV infection parameters with special impact on disease progression. TGF-beta(1) concentrations were measured by ELISA in the plasma of 66 patients in different stages of HIV infection and 20 healthy controls. HIV infection resulted in a significant increase of plasma TGF-beta(1) concentration compared to healthy individuals (11.4 +/- 6.8 vs. 6.1 +/- 1.5 ng/mL, p < 0.01). TGF-beta(1) values showed a significant negative correlation with CD4 cells count (r = -0.42, p = 0.001), as well as with CD8 cells count (r = -0.031, p < 0.05). Moreover, patients with the symptomatic phase of HIV infection presented an almost twofold increase of plasma TGF-beta(1) concentration in comparison to asymptomatic patients and healthy individuals. Our results demonstrate the relationship between TGF-beta(1) concentrations and HIV infection advancement with marked elevation in the late stages of the disease. These findings support in vitro observations suggesting an important, immunosuppressive role of TGF-beta(1) in HIV infection pathogenesis. | lld:pubmed |
| pubmed-article:15018667 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15018667 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15018667 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15018667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15018667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15018667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15018667 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15018667 | pubmed:issn | 0882-8245 | lld:pubmed |
| pubmed-article:15018667 | pubmed:author | pubmed-author:ProkopowiczDa... | lld:pubmed |
| pubmed-article:15018667 | pubmed:author | pubmed-author:FlisiakRobert... | lld:pubmed |
| pubmed-article:15018667 | pubmed:author | pubmed-author:JaroszewiczJe... | lld:pubmed |
| pubmed-article:15018667 | pubmed:author | pubmed-author:Wierci?ska-Dr... | lld:pubmed |
| pubmed-article:15018667 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15018667 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:15018667 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15018667 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15018667 | pubmed:pagination | 109-13 | lld:pubmed |
| pubmed-article:15018667 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15018667 | pubmed:meshHeading | pubmed-meshheading:15018667... | lld:pubmed |
| pubmed-article:15018667 | pubmed:meshHeading | pubmed-meshheading:15018667... | lld:pubmed |
| pubmed-article:15018667 | pubmed:meshHeading | pubmed-meshheading:15018667... | lld:pubmed |
| pubmed-article:15018667 | pubmed:meshHeading | pubmed-meshheading:15018667... | lld:pubmed |
| pubmed-article:15018667 | pubmed:meshHeading | pubmed-meshheading:15018667... | lld:pubmed |
| pubmed-article:15018667 | pubmed:meshHeading | pubmed-meshheading:15018667... | lld:pubmed |
| pubmed-article:15018667 | pubmed:meshHeading | pubmed-meshheading:15018667... | lld:pubmed |
| pubmed-article:15018667 | pubmed:meshHeading | pubmed-meshheading:15018667... | lld:pubmed |
| pubmed-article:15018667 | pubmed:meshHeading | pubmed-meshheading:15018667... | lld:pubmed |
| pubmed-article:15018667 | pubmed:meshHeading | pubmed-meshheading:15018667... | lld:pubmed |
| pubmed-article:15018667 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15018667 | pubmed:articleTitle | Increased plasma transforming growth factor-beta1 is associated with disease progression in HIV-1-infected patients. | lld:pubmed |
| pubmed-article:15018667 | pubmed:affiliation | Department of Infectious Diseases, Medical University of Bialystok, Bialystok, Poland. alicja@priv.onet.pl | lld:pubmed |
| pubmed-article:15018667 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:7040 | entrezgene:pubmed | pubmed-article:15018667 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15018667 | lld:entrezgene |
| lhgdn:association:55984 | lhgdn:found_in | pubmed-article:15018667 | lld:lhgdn |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15018667 | lld:pubmed |
