Source:http://linkedlifedata.com/resource/pubmed/id/15018667
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2004-3-15
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| pubmed:abstractText |
Transforming growth factor-beta(1) (TGF-beta(1)) is a pleiotropic cytokine with a variety of effects on a wide range of cells in the immune system. Evidence suggests that TGF-beta(1) is also involved in the pathogenesis of human immunodeficiency virus type 1 infections. The aim of this study was to explore possible relationships between circulating TGF-beta(1) and immune as well as clinical HIV infection parameters with special impact on disease progression. TGF-beta(1) concentrations were measured by ELISA in the plasma of 66 patients in different stages of HIV infection and 20 healthy controls. HIV infection resulted in a significant increase of plasma TGF-beta(1) concentration compared to healthy individuals (11.4 +/- 6.8 vs. 6.1 +/- 1.5 ng/mL, p < 0.01). TGF-beta(1) values showed a significant negative correlation with CD4 cells count (r = -0.42, p = 0.001), as well as with CD8 cells count (r = -0.031, p < 0.05). Moreover, patients with the symptomatic phase of HIV infection presented an almost twofold increase of plasma TGF-beta(1) concentration in comparison to asymptomatic patients and healthy individuals. Our results demonstrate the relationship between TGF-beta(1) concentrations and HIV infection advancement with marked elevation in the late stages of the disease. These findings support in vitro observations suggesting an important, immunosuppressive role of TGF-beta(1) in HIV infection pathogenesis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0882-8245
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
17
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
109-13
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15018667-Adult,
pubmed-meshheading:15018667-Disease Progression,
pubmed-meshheading:15018667-Female,
pubmed-meshheading:15018667-HIV Infections,
pubmed-meshheading:15018667-HIV-1,
pubmed-meshheading:15018667-Humans,
pubmed-meshheading:15018667-Male,
pubmed-meshheading:15018667-Middle Aged,
pubmed-meshheading:15018667-Transforming Growth Factor beta,
pubmed-meshheading:15018667-Transforming Growth Factor beta1
|
| pubmed:year |
2004
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| pubmed:articleTitle |
Increased plasma transforming growth factor-beta1 is associated with disease progression in HIV-1-infected patients.
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| pubmed:affiliation |
Department of Infectious Diseases, Medical University of Bialystok, Bialystok, Poland. alicja@priv.onet.pl
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| pubmed:publicationType |
Journal Article
|