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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1992-9-17
|
| pubmed:abstractText |
Intraperitoneal administration of kainic acid (KA) into adult rats caused a profound increase in nerve growth factor (NGF) mRNA and a significant reduction of NGF protein level in the hippocampus. Diazepam pretreatment suppressed both. The reduction of NGF level was apparent in the dorsal hippocampus at 2 h after KA administration, but a marked elevation of NGF protein was observed in the ventral hippocampus at 4 h. These results suggest that non-N-methyl-D-aspartate (NMDA) receptor agonists negatively influence NGF synthesis or stimulate NGF protein degradation in the dorsal hippocampus involving the CA1 sector.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0304-3940
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
22
|
| pubmed:volume |
140
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
203-5
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1501779-Animals,
pubmed-meshheading:1501779-Blotting, Northern,
pubmed-meshheading:1501779-Diazepam,
pubmed-meshheading:1501779-Dose-Response Relationship, Drug,
pubmed-meshheading:1501779-Hippocampus,
pubmed-meshheading:1501779-Immunoenzyme Techniques,
pubmed-meshheading:1501779-Kainic Acid,
pubmed-meshheading:1501779-Male,
pubmed-meshheading:1501779-Nerve Growth Factors,
pubmed-meshheading:1501779-Rats,
pubmed-meshheading:1501779-Rats, Inbred Strains
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Reduction of NGF protein level in rat dorsal hippocampus following administration of kainic acid.
|
| pubmed:affiliation |
Institute of Biological Science, Mitsui Pharmaceuticals, Inc., Chiba, Japan.
|
| pubmed:publicationType |
Journal Article
|