Source:http://linkedlifedata.com/resource/pubmed/id/15015084
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2004-3-11
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pubmed:abstractText |
We study the lateral and transverse diffusion of amphiphiles in two-component bilayer membranes, using a coarse-grained model for amphiphilic molecules and combined Monte Carlo-Molecular Dynamics simulations. Membrane structural properties, such as the mean thickness, are also measured. The dependence of such properties on membrane composition, inter-molecular interactions, and amphiphile stiffness is determined. In particular, we show that addition of shorter amphiphiles drives the model membrane towards a more fluid state, with increased amphiphile lateral diffusion rates. These results can be understood in the framework of a simple free-volume model. Furthermore, we observe an increase in the trans-membrane diffusion when the interaction energy of amphiphiles with their neighboring molecules is decreased.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1292-8941
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
21-8
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pubmed:meshHeading |
pubmed-meshheading:15015084-Biological Transport,
pubmed-meshheading:15015084-Computer Simulation,
pubmed-meshheading:15015084-Diffusion,
pubmed-meshheading:15015084-Lipid Bilayers,
pubmed-meshheading:15015084-Membrane Fluidity,
pubmed-meshheading:15015084-Membrane Proteins,
pubmed-meshheading:15015084-Models, Biological,
pubmed-meshheading:15015084-Models, Molecular,
pubmed-meshheading:15015084-Porosity,
pubmed-meshheading:15015084-Reproducibility of Results,
pubmed-meshheading:15015084-Surface Properties,
pubmed-meshheading:15015084-Surface-Active Agents,
pubmed-meshheading:15015084-Water
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pubmed:year |
2003
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pubmed:articleTitle |
Lateral and transverse diffusion in two-component bilayer membranes.
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pubmed:affiliation |
Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Abteilung Theorie, D-14424 Potsdam, Germany. imparato@,pikg-golm.mpg.de
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pubmed:publicationType |
Journal Article,
Evaluation Studies
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