Source:http://linkedlifedata.com/resource/pubmed/id/15015070
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2004-4-16
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pubmed:abstractText |
Intravenous cyclophosphamide (IVCP) has been shown to be effective in lupus nephritis. This is a randomized controlled trial to compare the effectiveness of IVCP with oral cyclophosphamide (OCP) in patients with steroid-dependent (SD) idiopathic nephrotic syndrome (INS). Forty-seven consecutive children who were SD were randomized to receive either OCP (2 mg/kg per dayx12 weeks) or IVCP (500 mg/m(2) per month IVx6 months) after achieving a steroid-induced remission. The response was evaluated in terms of remission, change in steroid response status, duration of remission (i.e., proteinuria-free days), side effects, and compliance. Of the 47, IVCP was given to 26 children and OCP to 21 children. The demographic data, histopathology, biochemical profile, and duration of follow-up in the two groups were similar. On Kaplan-Meier survival analysis, the median proteinura-free time was 360+/-88 days compared with 96+/-88 days in the OCP group (values median+/-SE, log rank P=0.05). The actuarial cumulative sustained remission in our study was 73% in IVCP compared with 38.1% in OCP at 6 months after therapy, but was almost identical (18.6% in IVCP vs. 19%in OCP) after 2 years. Thus in our study the overall improvement in steroid response category from SD to sustained remission, infrequent relapser, and frequent relapser (88% in IVCP vs. 57% in OCP) was significantly better in the IVCP group, although the number of children with persistent remission tended to be similar at 2 years. Furthermore, the response was observed with a 40% lower cumulative dose than OCP. Hence, we conclude that IVCP is a safe and effective therapeutic modality in children with INS who are SD.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0931-041X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
494-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15015070-Administration, Oral,
pubmed-meshheading:15015070-Adolescent,
pubmed-meshheading:15015070-Anti-Inflammatory Agents,
pubmed-meshheading:15015070-Antineoplastic Agents, Alkylating,
pubmed-meshheading:15015070-Child,
pubmed-meshheading:15015070-Child, Preschool,
pubmed-meshheading:15015070-Cyclophosphamide,
pubmed-meshheading:15015070-Female,
pubmed-meshheading:15015070-Humans,
pubmed-meshheading:15015070-Infant,
pubmed-meshheading:15015070-Injections, Intravenous,
pubmed-meshheading:15015070-Male,
pubmed-meshheading:15015070-Nephrotic Syndrome,
pubmed-meshheading:15015070-Prednisolone,
pubmed-meshheading:15015070-Survival Analysis
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pubmed:year |
2004
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pubmed:articleTitle |
Pulse cyclophosphamide therapy in steroid-dependent nephrotic syndrome.
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pubmed:affiliation |
Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
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