rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
|
pubmed:dateCreated |
2004-3-11
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pubmed:abstractText |
Prostate cancer metastasizes to the skeleton to form osteoblastic lesions. Androgen ablation is the current treatment for metastatic prostate cancer. This therapy is palliative, and the disease will return in an androgen-independent form that is preceded by a rising titer of prostate-specific antigen (PSA). Here, we investigated the possibility that human osteoblasts might secrete factors that contribute to the emergence of androgen-independent prostate cancer.
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pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
1078-0432
|
pubmed:author |
pubmed-author:BlaszczykNatalieN,
pubmed-author:BruchovskyNicholasN,
pubmed-author:DuncanClive PCP,
pubmed-author:JonesEdward CEC,
pubmed-author:MasriBassam ABA,
pubmed-author:MawjiNasrin RNR,
pubmed-author:McAlindenGavanG,
pubmed-author:SadarMarianne DMD,
pubmed-author:SchnabelDorisD,
pubmed-author:SchweikertHans-UdoHU,
pubmed-author:UedaTakeshiT
|
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
10
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1860-9
|
pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15014041-Androgens,
pubmed-meshheading:15014041-Cell Division,
pubmed-meshheading:15014041-Cell Line, Tumor,
pubmed-meshheading:15014041-Genes, Reporter,
pubmed-meshheading:15014041-Humans,
pubmed-meshheading:15014041-Interleukin-6,
pubmed-meshheading:15014041-Luciferases,
pubmed-meshheading:15014041-Male,
pubmed-meshheading:15014041-Osteoblasts,
pubmed-meshheading:15014041-Prostate-Specific Antigen,
pubmed-meshheading:15014041-Prostatic Neoplasms,
pubmed-meshheading:15014041-Receptors, Androgen,
pubmed-meshheading:15014041-Recombinant Proteins,
pubmed-meshheading:15014041-Transfection
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pubmed:year |
2004
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pubmed:articleTitle |
Osteoblast-derived factors induce androgen-independent proliferation and expression of prostate-specific antigen in human prostate cancer cells.
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pubmed:affiliation |
Department of Cancer Endocrinology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|