| pubmed-article:15013753 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15013753 | lifeskim:mentions | umls-concept:C0026844 | lld:lifeskim |
| pubmed-article:15013753 | lifeskim:mentions | umls-concept:C1135918 | lld:lifeskim |
| pubmed-article:15013753 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:15013753 | pubmed:issue | 1-3 | lld:pubmed |
| pubmed-article:15013753 | pubmed:dateCreated | 2004-3-11 | lld:pubmed |
| pubmed-article:15013753 | pubmed:abstractText | Rev-erbalpha and retinoic acid receptor-related orphan receptor-alpha (RORalpha) are orphan nuclear receptors but their effects on transcription are opposed. Here, we show that Rev-erbalpha was expressed predominantly in vascular smooth muscle cells (VSMCs) rather than endothelial cells. Overexpression of Rev-erbalpha upregulated the expression of interleukin-6 and cyclooxygenase-2, and increased transactivation by NF-kappaB and translocation of p65 to the nucleus in A7r5 VSMCs. Furthermore, the expression of Rev-erbalpha was upregulated by RORalpha1 but that upregulation was attenuated by Rev-erbalpha itself in A7r5 VSMCs. These results suggest a regulatory link between Rev-erbalpha and the NF-kappaB pathway. | lld:pubmed |
| pubmed-article:15013753 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15013753 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15013753 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15013753 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15013753 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15013753 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15013753 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15013753 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15013753 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15013753 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15013753 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:15013753 | pubmed:author | pubmed-author:MorserJohnJ | lld:pubmed |
| pubmed-article:15013753 | pubmed:author | pubmed-author:MigitaHideyuk... | lld:pubmed |
| pubmed-article:15013753 | pubmed:author | pubmed-author:KawaiKohichiK | lld:pubmed |
| pubmed-article:15013753 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15013753 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:15013753 | pubmed:volume | 561 | lld:pubmed |
| pubmed-article:15013753 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15013753 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15013753 | pubmed:pagination | 69-74 | lld:pubmed |
| pubmed-article:15013753 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15013753 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15013753 | pubmed:articleTitle | Rev-erbalpha upregulates NF-kappaB-responsive genes in vascular smooth muscle cells. | lld:pubmed |
| pubmed-article:15013753 | pubmed:affiliation | Cardiovascular Research, Drug Discovery Institute, Nihon Schering K.K., 1900-1, Togo Mobara, Chiba 297-0017, Japan. hmigita@schering.co.jp | lld:pubmed |
| pubmed-article:15013753 | pubmed:publicationType | Journal Article | lld:pubmed |
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