|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1-3
|
|
pubmed:dateCreated |
2004-3-11
|
|
pubmed:abstractText |
Rev-erbalpha and retinoic acid receptor-related orphan receptor-alpha (RORalpha) are orphan nuclear receptors but their effects on transcription are opposed. Here, we show that Rev-erbalpha was expressed predominantly in vascular smooth muscle cells (VSMCs) rather than endothelial cells. Overexpression of Rev-erbalpha upregulated the expression of interleukin-6 and cyclooxygenase-2, and increased transactivation by NF-kappaB and translocation of p65 to the nucleus in A7r5 VSMCs. Furthermore, the expression of Rev-erbalpha was upregulated by RORalpha1 but that upregulation was attenuated by Rev-erbalpha itself in A7r5 VSMCs. These results suggest a regulatory link between Rev-erbalpha and the NF-kappaB pathway.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NR1D1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Subfamily 1...,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Subfamily 1...,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/RORA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor RelA
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0014-5793
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
12
|
|
pubmed:volume |
561
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
69-74
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:15013753-Aorta,
pubmed-meshheading:15013753-Cyclooxygenase 2,
pubmed-meshheading:15013753-DNA-Binding Proteins,
pubmed-meshheading:15013753-Humans,
pubmed-meshheading:15013753-Inflammation,
pubmed-meshheading:15013753-Interleukin-6,
pubmed-meshheading:15013753-Isoenzymes,
pubmed-meshheading:15013753-Membrane Proteins,
pubmed-meshheading:15013753-Muscle, Smooth, Vascular,
pubmed-meshheading:15013753-Myocytes, Smooth Muscle,
pubmed-meshheading:15013753-NF-kappa B,
pubmed-meshheading:15013753-Nuclear Receptor Subfamily 1, Group D, Member 1,
pubmed-meshheading:15013753-Nuclear Receptor Subfamily 1, Group F, Member 1,
pubmed-meshheading:15013753-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:15013753-Receptor Cross-Talk,
pubmed-meshheading:15013753-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:15013753-Tissue Distribution,
pubmed-meshheading:15013753-Trans-Activators,
pubmed-meshheading:15013753-Transcription Factor RelA,
pubmed-meshheading:15013753-Transcriptional Activation,
pubmed-meshheading:15013753-Umbilical Veins,
pubmed-meshheading:15013753-Up-Regulation
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Rev-erbalpha upregulates NF-kappaB-responsive genes in vascular smooth muscle cells.
|
|
pubmed:affiliation |
Cardiovascular Research, Drug Discovery Institute, Nihon Schering K.K., 1900-1, Togo Mobara, Chiba 297-0017, Japan. hmigita@schering.co.jp
|
|
pubmed:publicationType |
Journal Article
|
