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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-3-11
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pubmed:abstractText |
Human cytomegalovirus UL18, a MHC class I homologue, is known to serve as a natural killer cell (NK) decoy and to ligate NK inhibitory receptors to prevent lysis of an infected target cell. To explore whether the cell surface expression of UL18 represents a potential immune suppressive approach to evade NK-mediated cytotoxicity in the prevention of xenograft rejection, we examined the effect of the UL18 expression in vitro upon human NK-mediated cytotoxicity against swine endothelial cells (SECs). UL18 expression on SECs by a retroviral vector (PLNCX2) significantly suppressed NK-mediated SEC lysis by approximately 25-100%. The protective effect of UL18 could be mediated through ILT-2 inhibitory receptor on NKs. Additionally, the interaction between UL18 and NKs resulted in the significant reduction of IFN-gamma production. This study demonstrates that UL18 can serve as an effective tool for the evasion of NK-mediated cytotoxicity and for the inhibition of IFN-gamma production during xenograft rejection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Capsid Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HLA Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-G Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/LILRB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/VP23 protein, Human herpesvirus 1
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-291X
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pubmed:author |
pubmed-author:AhnCurieC,
pubmed-author:ChaChang-YongCY,
pubmed-author:ChoiSeung-EunSE,
pubmed-author:HaJongwonJ,
pubmed-author:HwangEung-SooES,
pubmed-author:KimJae-YoungJY,
pubmed-author:KimJung-SikJS,
pubmed-author:KimSang-JoonSJ,
pubmed-author:MiyagawaShujiS,
pubmed-author:ParkChung-GyuCG,
pubmed-author:YunIl-HeeIH
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
315
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
144-50
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15013438-Animals,
pubmed-meshheading:15013438-Antigens, CD,
pubmed-meshheading:15013438-Capsid Proteins,
pubmed-meshheading:15013438-Cell Line,
pubmed-meshheading:15013438-Cell Membrane,
pubmed-meshheading:15013438-Cytotoxicity, Immunologic,
pubmed-meshheading:15013438-Endothelium, Vascular,
pubmed-meshheading:15013438-Flow Cytometry,
pubmed-meshheading:15013438-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:15013438-HLA Antigens,
pubmed-meshheading:15013438-HLA-G Antigens,
pubmed-meshheading:15013438-Histocompatibility Antigens Class I,
pubmed-meshheading:15013438-Humans,
pubmed-meshheading:15013438-Interferon-gamma,
pubmed-meshheading:15013438-Killer Cells, Natural,
pubmed-meshheading:15013438-Receptors, Immunologic,
pubmed-meshheading:15013438-Recombinant Proteins,
pubmed-meshheading:15013438-Swine,
pubmed-meshheading:15013438-Transfection,
pubmed-meshheading:15013438-Transplantation, Heterologous
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pubmed:year |
2004
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pubmed:articleTitle |
Human cytomegalovirus UL18 alleviated human NK-mediated swine endothelial cell lysis.
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pubmed:affiliation |
Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 110-799, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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