Linked Life Data

15011593

Source:http://linkedlifedata.com/resource/pubmed/id/15011593

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2004-3-11
pubmed:abstractText
Resistance-associated mutations of the HIV genome are one major reason for failure of highly, active antiretroviral therapy. The accumulation of resistance is demonstrated by data from the HCUS-study, where resistant virus strains were isolated in about 50%. More than 60% of the patients showed therapy failure in this survey, and resistance was found in almost 80% of these. Mutations in the HIV genome were also described in treatment-naive patients. In the German Seroconverter Study the rate of resistance was 12%, in a multicenter study in Nordrhein-Westfalen resistant isolates were found in 14% of chronically infected cases. The wide distribution of HIV resistance in treated and untreated patients is an important problem in the management of HIV-infection. It requires a rational application of resistance testing. International studies are under way to further characterize the relevance of the phenomenon of HIV resistance.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1438-3276
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
145 Spec No 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
58-61
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
[HIV resistance. More the rule than an exception].
pubmed:affiliation
Klinik für Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinikum Düsseldorf. oettem@med.uni-duesseldorf.de
pubmed:publicationType
Journal Article, English Abstract