Linked Life Data

15010126

Source:http://linkedlifedata.com/resource/pubmed/id/15010126

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2004-3-10
pubmed:abstractText
The present study was carried out to evaluate the possibility of using the polymer EVA membrane as an EVA matrix system for transdermal delivery of atenolol. The effects of drug concentration, temperature, and plasticizers on drug release were studied from the atenolol-EVA matrix. The release rate of drug from the EVA matrix increased with increased temperature and drug loading doses. The flux of atenolol versus the reciprocal of the loading dose yielded a straight line. The release of atenolol from the EVA matrix follows a diffusion-controlled model, where the quantity released per unit area is proportional to the square root of time. Among the plasticizers used such as alkyl citrates and phthalates, tributyl citrate (TBC) showed the best enhancing effects. Enhancement factor of TBC was 1.51 from the EVA matrix at 37 degrees C. The controlled release of atenolol system could be developed using the EVA polymer including the plasticizer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0378-5173
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
273
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
23-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Controlled release of atenolol from the ethylene-vinyl acetate matrix.
pubmed:affiliation
College of Pharmacy, Chonnam National University, 300 Yongbongdong, Bukku, Gwangju 500-757, South Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't