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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-3-10
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pubmed:abstractText |
Single nucleotide polymorphisms in the tumour necrosis factor alpha (TNF-alpha) promoter region may modulate TNF-alpha gene transcriptional activity by modifying the binding of transcription factors. Here we confirm that a specific DNA complex binds preferentially the variant TNF2 allele in various cell types and demonstrate that activating protein (AP)-2, myeloid zinc finger gene 1 (MZF-1) and Sp1 are not involved in this complex.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-7420
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
15-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15009176-Alleles,
pubmed-meshheading:15009176-B-Lymphocytes,
pubmed-meshheading:15009176-Binding, Competitive,
pubmed-meshheading:15009176-Binding Sites,
pubmed-meshheading:15009176-Cell Line,
pubmed-meshheading:15009176-Cell Line, Tumor,
pubmed-meshheading:15009176-Cell Nucleus,
pubmed-meshheading:15009176-Cell Survival,
pubmed-meshheading:15009176-DNA,
pubmed-meshheading:15009176-DNA-Binding Proteins,
pubmed-meshheading:15009176-Dose-Response Relationship, Drug,
pubmed-meshheading:15009176-Flow Cytometry,
pubmed-meshheading:15009176-Humans,
pubmed-meshheading:15009176-Kruppel-Like Transcription Factors,
pubmed-meshheading:15009176-Monocytes,
pubmed-meshheading:15009176-Oligonucleotides,
pubmed-meshheading:15009176-Polymorphism, Genetic,
pubmed-meshheading:15009176-Polymorphism, Single Nucleotide,
pubmed-meshheading:15009176-Promoter Regions, Genetic,
pubmed-meshheading:15009176-Protein Binding,
pubmed-meshheading:15009176-Sp1 Transcription Factor,
pubmed-meshheading:15009176-T-Lymphocytes,
pubmed-meshheading:15009176-Transcription Factor AP-2,
pubmed-meshheading:15009176-Transcription Factors,
pubmed-meshheading:15009176-Tumor Necrosis Factor-alpha
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pubmed:year |
2004
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pubmed:articleTitle |
Allele-specific binding to the -308 single nucleotide polymorphism site in the tumour necrosis factor-alpha promoter.
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pubmed:affiliation |
Equipe d'Accueil 3737 Pathologie des Cellules Lymphoïdes, Claude Bernard University, Lyon, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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