15008556

Source:http://linkedlifedata.com/resource/pubmed/id/15008556

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0018270, umls-concept:C0027092, umls-concept:C0205131, umls-concept:C0205296, umls-concept:C0442802, umls-concept:C0723457, umls-concept:C1417022, umls-concept:C1527148, umls-concept:C1710082, umls-concept:C1947925, umls-concept:C2746065
pubmed:issue	1
pubmed:dateCreated	2004-3-10
pubmed:abstractText	Myopia is emerging as a major public health issue due to its increasing prevalence and long-term pathological outcomes. Prevention must focus on limiting excessive axial elongation which is the cause of both myopic refractive error and its pathological outcomes. The increasing prevalence appears to be due to environmental changes involving near work, rather than to a genetic failure of emmetropisation. Attempts to control the progression of myopia optically have been unsuccessful; the only available preventive regime involves the use of atropine eye drops. This regime has short-term side effects, and since the site and mechanism of action of muscarinic antagonists are unclear, there are concerns about its long-term safety. Recent studies on natural STOP growth signals suggest that they are evoked by relatively brief periods of imposed myopic defocus, and can overcome strong pressures towards increased axial elongation. While STOP signals have only been successfully used in chickens to prevent excessive axial elongation, similar signals are generated in mammals and non-human primates. Further studies may define the conditions under which this approach could be used to prevent the development of myopia in humans.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7503289
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Jan
pubmed:issn	0304-4602
pubmed:author	pubmed-author:MegasTT, pubmed-author:MorganII
pubmed:issnType	Print
pubmed:volume	33
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	16-20
pubmed:dateRevised	2005-11-16
pubmed:meshHeading	pubmed-meshheading:15008556-Accommodation, Ocular, pubmed-meshheading:15008556-Animals, pubmed-meshheading:15008556-Eye, pubmed-meshheading:15008556-Genetic Predisposition to Disease, pubmed-meshheading:15008556-Humans, pubmed-meshheading:15008556-Myopia, pubmed-meshheading:15008556-Retina
pubmed:year	2004
pubmed:articleTitle	Using natural STOP growth signals to prevent excessive axial elongation and the development of myopia.
pubmed:affiliation	Visual Sciences Group, Research School of Biological Sciences and Centre for Visual Science, Australian National University, Canberra City, ACT, Australia. ian.morgan@anu.edu.au
pubmed:publicationType	Journal Article, Review