Linked Life Data

15008240

Source:http://linkedlifedata.com/resource/pubmed/id/15008240

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2004-3-10
pubmed:abstractText
Peroxisome proliferator activated receptor (PPAR)gamma plays a pivotal role in regulating adipocyte differentiation and metabolism, but also has an antiproliferative effect in several tissues, including colonic mucosa, where it is highly expressed. Loss-of-function mutations have been reported in about 10% of sporadic primary colon cancer. Acromegalic patients have an increased prevalence of colonic neoplasms and lower PPARgamma levels in the colonic mucosa. Thus, PPARgamma may act as a tumor suppressor gene, and its reduced expression or loss-of-function mutations may contribute to tumorigenesis. In this study the expression and mutations of the PPARgamma gene in the colonic polyps and mucosa outside polyps were investigated in 10 acromegalic and 17 non-acromegalic patients. PPARgamma expression was evaluated by RT-PCR. PPARgamma was expressed in each sample, but expression appeared to be lower in polyps than in mucosa outside polyps from either acromegalic or non-acromegalic patients. All exons of the PPARgamma gene were directly sequenced after PCR amplification: no mutations were found either in acromegalic or in non-acromegalic patients. In conclusion, the results of this preliminary study suggest that the lower expression of PPARgamma rather than somatic mutations of this gene is involved in colonic tumorigenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0391-4097
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1054-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15008240-Acromegaly, pubmed-meshheading:15008240-Colonic Neoplasms, pubmed-meshheading:15008240-Colonic Polyps, pubmed-meshheading:15008240-Female, pubmed-meshheading:15008240-Gene Expression Regulation, Neoplastic, pubmed-meshheading:15008240-Human Growth Hormone, pubmed-meshheading:15008240-Humans, pubmed-meshheading:15008240-Insulin-Like Growth Factor I, pubmed-meshheading:15008240-Intestinal Mucosa, pubmed-meshheading:15008240-Male, pubmed-meshheading:15008240-Middle Aged, pubmed-meshheading:15008240-Mutation, pubmed-meshheading:15008240-RNA, Neoplasm, pubmed-meshheading:15008240-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:15008240-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:15008240-Sequence Analysis, DNA, pubmed-meshheading:15008240-Transcription Factors
pubmed:year
2003
pubmed:articleTitle
Colonic polyps of acromegalic patients are not associated with mutations of the peroxisome proliferator activated receptor gamma gene.
pubmed:affiliation
Department of Endocrinology and Metabolism, and Oncology, University of Pisa, Pisa, Italy. f.bogazzi@endoc.med.unipi.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't