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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2004-3-23
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pubmed:abstractText |
We have previously validated the use of micro-positron emission tomography (microPET) for monitoring the expression of a single PET reporter gene in rat myocardium. We now report the use of a bicistronic adenoviral vector (Ad-CMV-D2R80a-IRES-HSV1-sr39tk) for linking the expression of 2 PET reporter genes, a mutant rat dopamine type 2 receptor (D2R80a) and a mutant herpes simplex virus type 1 thymidine kinase (HSV1-sr39tk), with the aid of an internal ribosomal entry site (IRES).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
23
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1415-20
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15007006-Adenoviridae,
pubmed-meshheading:15007006-Animals,
pubmed-meshheading:15007006-Cells, Cultured,
pubmed-meshheading:15007006-Defective Viruses,
pubmed-meshheading:15007006-Fluorine Radioisotopes,
pubmed-meshheading:15007006-Gene Expression Regulation, Viral,
pubmed-meshheading:15007006-Gene Therapy,
pubmed-meshheading:15007006-Genes, Reporter,
pubmed-meshheading:15007006-Genetic Vectors,
pubmed-meshheading:15007006-Guanine,
pubmed-meshheading:15007006-Heart,
pubmed-meshheading:15007006-Herpesvirus 1, Human,
pubmed-meshheading:15007006-Injections,
pubmed-meshheading:15007006-Myocardium,
pubmed-meshheading:15007006-Myocytes, Cardiac,
pubmed-meshheading:15007006-Radiopharmaceuticals,
pubmed-meshheading:15007006-Rats,
pubmed-meshheading:15007006-Rats, Nude,
pubmed-meshheading:15007006-Rats, Sprague-Dawley,
pubmed-meshheading:15007006-Receptors, Dopamine D2,
pubmed-meshheading:15007006-Recombinant Fusion Proteins,
pubmed-meshheading:15007006-Spiperone,
pubmed-meshheading:15007006-Thymidine Kinase,
pubmed-meshheading:15007006-Transduction, Genetic
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pubmed:year |
2004
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pubmed:articleTitle |
Micro-positron emission tomography imaging of cardiac gene expression in rats using bicistronic adenoviral vector-mediated gene delivery.
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pubmed:affiliation |
Crump Institute for Molecular Imaging, UCLA School of Medicine, Los Angeles, Calif 94305-5427, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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