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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-3-9
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pubmed:abstractText |
Mice carrying mutated human APPswe and PS1 (A246E) transgenes (A/P mice) show age-dependent memory impairment in hippocampus-dependent tasks. Moreover, the mice show normal learning in the water maze within a day but impairment across days. We recorded LTP in a slice preparation (CA1) and in chronically implanted animals (dentate gyrus, or DG) at 17-18 months of age. The genotypes did not differ in the basal synaptic transmission. Also, LTP induction and its maintenance over 60 min did not differ between A/P and control mice. However, the fEPSP enhancement in vivo decayed to 77% of its maximum in 24 h in A/P mice while remaining at 96% in control mice. The time course of the LTP decay in the A/P mice corresponds to their behavioral impairment and indicates that Abeta accumulation in the dentate gyrus may interfere with the signal transduction pathways responsible for memory consolidation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0969-9961
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
188-95
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15006688-Alzheimer Disease,
pubmed-meshheading:15006688-Amyloid beta-Peptides,
pubmed-meshheading:15006688-Amyloid beta-Protein Precursor,
pubmed-meshheading:15006688-Animals,
pubmed-meshheading:15006688-Dentate Gyrus,
pubmed-meshheading:15006688-Disease Models, Animal,
pubmed-meshheading:15006688-Excitatory Postsynaptic Potentials,
pubmed-meshheading:15006688-Hippocampus,
pubmed-meshheading:15006688-Humans,
pubmed-meshheading:15006688-Long-Term Potentiation,
pubmed-meshheading:15006688-Male,
pubmed-meshheading:15006688-Membrane Proteins,
pubmed-meshheading:15006688-Memory Disorders,
pubmed-meshheading:15006688-Mice,
pubmed-meshheading:15006688-Mice, Transgenic,
pubmed-meshheading:15006688-Phenotype,
pubmed-meshheading:15006688-Plaque, Amyloid,
pubmed-meshheading:15006688-Presenilin-1,
pubmed-meshheading:15006688-Synaptic Transmission
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pubmed:year |
2004
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|
pubmed:articleTitle |
Normal induction but accelerated decay of LTP in APP + PS1 transgenic mice.
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pubmed:affiliation |
Department of Neuroscience and Neurology, University of Kuopio, 70211 Kuopio, Finland.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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