Source:http://linkedlifedata.com/resource/pubmed/id/15006423
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2004-3-9
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pubmed:abstractText |
White spot syndrome, caused by white spot syndrome virus (WSSV), is a deadly disease of shrimps, causing a catastrophic loss in shrimp industries worldwide. In order to investigate molecular response of shrimp haemocyte to WSSV infection, we performed subtraction hybridization of mRNAs from healthy and WSSV-infected haemocyte. One of the genes that were severely down-regulated in moribund WSSV-infected-haemocyte was translationally controlled tumor protein (TCTP) (or fortilin). Strikingly, while there was a slight difference in the amount of TCTP message between normal and early WSSV-infected shrimps, shrimps that exhibited severe symptoms uniformly had very little TCTP in their haemocyte. Taken together with the fact that TCTP functions as an anti-apoptotic protein in mammals, our data suggest that TCTP in shrimp protects WSSV-infected shrimps from death.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0168-1656
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
219-26
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15006423-Amino Acid Sequence,
pubmed-meshheading:15006423-Animals,
pubmed-meshheading:15006423-Calcium,
pubmed-meshheading:15006423-Cloning, Molecular,
pubmed-meshheading:15006423-Escherichia coli,
pubmed-meshheading:15006423-Gene Expression Regulation,
pubmed-meshheading:15006423-Mammals,
pubmed-meshheading:15006423-Molecular Sequence Data,
pubmed-meshheading:15006423-Penaeidae,
pubmed-meshheading:15006423-Protein Binding,
pubmed-meshheading:15006423-Tumor Markers, Biological
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pubmed:year |
2004
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pubmed:articleTitle |
Molecular cloning and expression of a mammalian homologue of a translationally controlled tumor protein (TCTP) gene from Penaeus monodon shrimp.
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pubmed:affiliation |
Department of Biochemistry, Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla 90110, Thailand.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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