Source:http://linkedlifedata.com/resource/pubmed/id/15006383
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2004-3-9
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| pubmed:abstractText |
The stable conformations of GABA(A)-benzodiazepine receptor bivalent ligands 2 and 3 were determined by low temperature NMR spectroscopy and confirmed by single crystal X-ray analysis. The linear conformation was important for these dimers to access the binding site and exhibit potent in vitro affinity as illustrated for alpha5 subtype selective ligand 2 (15 nM). Bivalent ligand 3 with the 5 atom linker folded back upon itself both in solution and in the solid state, moreover, it did not bind to Bz receptors.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0960-894X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
22
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1465-9
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:15006383-Crystallography, X-Ray,
pubmed-meshheading:15006383-Ligands,
pubmed-meshheading:15006383-Molecular Conformation,
pubmed-meshheading:15006383-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:15006383-Protein Binding,
pubmed-meshheading:15006383-Receptors, GABA-A,
pubmed-meshheading:15006383-Temperature
|
| pubmed:year |
2004
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| pubmed:articleTitle |
Determination of the stable conformation of GABA(A)-benzodiazepine receptor bivalent ligands by low temperature NMR and X-ray analysis.
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| pubmed:affiliation |
Department of Chemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, 53201, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|