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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2004-3-9
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pubmed:abstractText |
The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key region of ZipA involved in FtsZ binding. The X-ray crystal structure of one of these molecules complexed with ZipA was solved. The structure revealed an unexpected binding mode, facilitated by desolvation of a loosely bound surface water.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Escherichia coli Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/FtsZ84 protein, E coli,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Quinazolines,
http://linkedlifedata.com/resource/pubmed/chemical/ZipA protein, E coli,
http://linkedlifedata.com/resource/pubmed/chemical/indolo(2,1-b)quinazoline
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:DingWeidongW,
pubmed-author:DushinElizabeth GEG,
pubmed-author:ForemanKen WKW,
pubmed-author:JenningsLee DLD,
pubmed-author:KennyCynthia HessCH,
pubmed-author:LiYuanhongY,
pubmed-author:MoghazehSoraya LSL,
pubmed-author:MosyakLidiaL,
pubmed-author:PetersenPeter JPJ,
pubmed-author:RushThomas STS3rd,
pubmed-author:RuzinAlexey VAV,
pubmed-author:SukhdeoMohani NMN,
pubmed-author:SutherlandAlan GAG,
pubmed-author:TsaoDesiree H HDH,
pubmed-author:TuckmanMargaretaM
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1427-31
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
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pubmed:year |
2004
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pubmed:articleTitle |
Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction.
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pubmed:affiliation |
Wyeth Research, Department of Medicinal Chemistry, 401N. Middletown Rd, Pearl River, NY 10965, USA. jenninl@wyeth.com
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pubmed:publicationType |
Journal Article
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