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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2004-3-9
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pubmed:abstractText |
Solid-phase synthetic methods for biaryl-based compounds were developed resulting in the construction of two 1000-member libraries. Numerous compounds were identified by high-throughput screening using whole cell screens to exhibit anti-microbial activity against Gram-positive bacteria. A series of biaryl compounds containing natural and unnatural amino acids were made to explore the SAR of the amino acid functionality.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:DiasTracy MTM,
pubmed-author:FangFloraF,
pubmed-author:HoSunS,
pubmed-author:HromockyjAlexander EAE,
pubmed-author:LeeLaurance LLL,
pubmed-author:LookGary CGC,
pubmed-author:MarraAndreaA,
pubmed-author:MurphyMartin MMM,
pubmed-author:SchullekJohn RJR,
pubmed-author:TranThuy HTH,
pubmed-author:VacinCharlesC,
pubmed-author:WestmacottDonD,
pubmed-author:WiesnerCedricC
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1423-6
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pubmed:meshHeading |
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pubmed:year |
2004
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pubmed:articleTitle |
The discovery of biaryl acids and amides exhibiting antibacterial activity against Gram-positive bacteria.
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pubmed:affiliation |
Rigel Inc., 1180 Veterans Blvd., South San Francisco, CA 94080, USA.
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pubmed:publicationType |
Journal Article
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