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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-3-8
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pubmed:abstractText |
Methylenetetrahydrofolate reductase (MTHFR) is one of the enzymes involved in folate metabolism and DNA methylation and synthesis. Some genotypes of this highly polymorphic enzyme are associated with decreased activity. Previous studies have suggested that individuals with the MTHFR 677TT, 1298AC and 1298CC have a lower risk of adult acute lymphoblastic leukemia (ALL).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1592-8721
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pubmed:author |
pubmed-author:BartolozziFrancescoF,
pubmed-author:ChiusoloPatriziaP,
pubmed-author:CiminoGiuseppeG,
pubmed-author:FarinaGiulianaG,
pubmed-author:FaziPaolaP,
pubmed-author:FioriniAlessiaA,
pubmed-author:LaurentiLucaL,
pubmed-author:LeoneGiuseppeG,
pubmed-author:MandelliFrancoF,
pubmed-author:ReddicontoGiovanniG,
pubmed-author:SicaSimonaS,
pubmed-author:SoràFedericaF,
pubmed-author:VitaleAntonellaA
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pubmed:issnType |
Electronic
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
139-44
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15003888-Alleles,
pubmed-meshheading:15003888-Amino Acid Substitution,
pubmed-meshheading:15003888-DNA Mutational Analysis,
pubmed-meshheading:15003888-Gene Frequency,
pubmed-meshheading:15003888-Genetic Predisposition to Disease,
pubmed-meshheading:15003888-Genotype,
pubmed-meshheading:15003888-Humans,
pubmed-meshheading:15003888-Hyperhomocysteinemia,
pubmed-meshheading:15003888-Italy,
pubmed-meshheading:15003888-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:15003888-Mutation, Missense,
pubmed-meshheading:15003888-Point Mutation,
pubmed-meshheading:15003888-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:15003888-Prevalence,
pubmed-meshheading:15003888-Risk
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pubmed:year |
2004
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pubmed:articleTitle |
Methylenetetrahydrofolate reductase genotypes do not play a role in acute lymphoblastic leukemia pathogenesis in the Italian population.
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pubmed:affiliation |
Istituto di Ematologia, Policlinico Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy. p.chiusolo@rm.unicatt.it
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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