Linked Life Data

1500305

Source:http://linkedlifedata.com/resource/pubmed/id/1500305

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1992-9-17
pubmed:abstractText
The aim of the investigation was to determine in an animal model the time required for cochlear changes to appear after cisplatin therapy, i.e. whether there is any late ototoxicity detectable. For this purpose we performed histochochleographic studies in the laboratory rat. In two trials different groups of 6-7 rats were given a single daily dose of 2 mg/kg body wt. cisplatin over 5 days. After various periods of time surface preparations of the organ of Corti were performed. The results obtained showed that cochlear damage was evident as early as 4 days after the final injection of drug and no further significant changes in cochlear damage could be seen during the period of observation.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0017-6192
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
271-6
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
[Histocochleographic studies of the late toxicity of cisplatin].
pubmed:affiliation
Universitäts-HNO-Klinik und Poliklinik, Homburg/Saar.
pubmed:publicationType
Journal Article, English Abstract